MDR1 and multidrug resistance-associated protein (MRP) gene expression in epithelial ovarian tumors

Cancer Letters
M KavallarisM L Friedlander

Abstract

Clinical drug resistance poses a major problem in the successful treatment of ovarian cancer. Two genes, MDR1 and MRP, have been found to play a role in the multidrug resistance phenotype of a number of human tumors. Using a sensitive semiquantitative PCR assay we examined 53 primary untreated ovarian tumors for expression of both MDR1 and MRP genes. Approximately one-third of the tumors expressed MDR1 while all the tumors expressed varying levels of the MRP gene.

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Dec 21, 2000·Current Oncology Reports·P M Fracasso
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Jan 5, 2019·Molecular Cancer Research : MCR·Christopher BreedHeidi K Baumgartner

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