PMID: 11337937May 8, 2001Paper

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

Pharmacogenetics
M M AmeyawH L McLeod

Abstract

P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression is an important factor regulating absorption of a wide variety of medications. It has also been associated with intrinsic and acquired cross resistance to a number of structurally unrelated anticancer drugs. A single nucleotide polymorphism (SNP) in exon 26 of the MDR1 gene, C3435T, was recently correlated with PGP protein levels and substrate uptake. Individuals homozygous for the T allele have more than four-fold lower PGP expression compared with CC individuals. As overexpression of PGP has been associated with altered drug absorption, therapy-resistant malignancies, and lower concentrations of HIV-1 protease inhibitors, this SNP may provide a useful approach to individualize therapy. To facilitate clinical application throughout the world, 1280 subjects from 10 different ethnic groups were evaluated for this SNP using the polymerase chain reaction-restriction fragment length polymorphism assay and the genotype and allele frequency for each group were ascertained. Marked differences in genotype and allele frequency were apparent between the African popu...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·I A de Lannoy, M Silverman
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
Dec 30, 1986·Biochemical and Biophysical Research Communications·K UedaJ R Riordan
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A T FojoI Pastan
Jan 1, 1995·Annual Review of Genetics·M M GottesmanI Pastan
Feb 7, 1998·The Journal of Clinical Investigation·R B KimG R Wilkinson
Feb 5, 1999·Human Molecular Genetics·M M AmeyawH L McLeod
Feb 5, 1999·Human Molecular Genetics·Y Y HonW E Evans
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds

❮ Previous
Next ❯

Citations

Sep 5, 2002·Journal of Surgical Oncology·Holly L NeibergsJohn S Spratt
Jan 18, 2007·Archives of Pharmacal Research·Ho-Cheol RyuDong-Kwon Rhee
Sep 29, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Caroline F SamerJules A Desmeules
Apr 22, 2008·Molecular Diagnosis & Therapy·Yongfang LiSiamak Davani
Feb 5, 2005·European Journal of Clinical Pharmacology·Aurel C AllabiJean-Luc Gala
May 6, 2009·International Journal of Colorectal Disease·Mariusz PanczykMarek Mirowski
Feb 12, 2011·International Journal of Legal Medicine·Anu M NeuvonenAntti Sajantila
Feb 27, 2007·Cancer Metastasis Reviews·Ying Huang
Sep 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei-Xia ZhangHong-Hao Zhou
May 14, 2005·Pharmacology & Therapeutics·Thomas Efferth, Manfred Volm
Jun 5, 2003·Biochemical Pharmacology·Naomi MoritaKazuo Nakayama
Oct 31, 2002·Advanced Drug Delivery Reviews·Martin F Fromm
Oct 16, 2003·Genomics·Jörn LötschGerd Geisslinger
May 6, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alex SparreboomWilliam D Figg
Apr 18, 2012·Journal of Medicinal Chemistry·Stephen A Hitchcock
Mar 26, 2002·The Pharmacogenomics Journal·M A Rothstein, P G Epps
Mar 23, 2002·The Pharmacogenomics Journal·M Pirmohamed, D J Back
Jan 17, 2007·The Pharmacogenomics Journal·S MarshT W Synold
Jun 24, 2009·The Pharmacogenomics Journal·J L Yen-RevolloS Marsh
Aug 5, 2009·The Pharmacogenomics Journal·H VisscherM R Hayden
May 8, 2002·British Journal of Clinical Pharmacology·Siegfried DrescherMartin F Fromm
Sep 8, 2001·The New England Journal of Medicine·H L McLeod
Feb 7, 2003·The New England Journal of Medicine·William E Evans, Howard L McLeod
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erin QuirkWilliam Powderly
Aug 9, 2002·AIDS Research and Human Retroviruses·Thomas F KresinaLaura W Cheever
Apr 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tabrez JafarSuraksha Agrawal
Aug 15, 2006·Pharmacogenetics and Genomics·Jean Nicholas RoyMichel Roger
May 13, 2009·American Journal of Therapeutics·Joseph Prandota
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Tomomitsu TaharaHiroshi Nakano
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Sanjay U C SankatsingJan M Prins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.