PMID: 7529122Sep 1, 1994Paper

ME1-antibody labelling of primary bronchogenic tumours and extrapulmonary malignancies

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
B G SkovF Hirsch

Abstract

ME1 is a monoclonal antibody which is generated by the use of a mesothelioma cell line (SPCIII). The antibody has a preferential reaction to antigens on mesothelial and mesothelioma cells. In a prospective study we determined the reactivity in frozen sections from malignant mesotheliomas (two cases, positive controls), lung tumours (115 cases) and other malignant tumours (23 cases). The two malignant mesotheliomas were immunoreactive in most of the tumour cells. The reaction was strong, often with a diffuse staining of the cytoplasm and in some tumour cells there was heavy staining of the cell membrane. Five adenocarcinomas of the lung (9%), one large cell carcinoma (10%) and 18 squamous cell carcinomas of the lung (41%) were positive (defined as tumours containing more than 10% positive tumour cells with a strong reaction). The same was true for seven out of 23 (30%) extrapulmonary malignancies. The overall nosologic specificity of ME1 was 76%. Twenty out of the 26 ME1-positive lung tumours and six out of seven ME1-positive extrapulmonary malignancies were also positive for one or more markers, which is considered characteristic of carcinomas. The six negative lung tumours were squamous cells carcinomas and the negative extrap...Continue Reading

Citations

Feb 14, 1998·Journal of Clinical Pathology·A D KennedyK M Kerr
Nov 13, 2003·Postgraduate Medical Journal·S K Mohanty, P Dey
Jan 1, 1997·Pathology, Research and Practice·P G BettaC Magnani
Oct 19, 2006·Seminars in Diagnostic Pathology·Cornelius KachaliDavid C Chhieng
Aug 1, 1997·Human Pathology·A V MasangkayE Kahn
Sep 1, 1996·The American Journal of Surgical Pathology·C DoglioniG Viale

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