Meal-exercise challenge and physical activity reduction impact on immunity and inflammation (MERIIT trial)

Contemporary Clinical Trials Communications
Diana SilvaAndré Moreira

Abstract

The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2) the impact of an induced acute period of sedentary behavior on neuro-immune-endocrine status. /Design: This is a two steps clinical trial including: (a) randomized crossover clinical trial, comparing the effect a high-fat/low-nutrient dense meal, FFM, with an isoenergetic similar high-nutrient dense meal, MdM, in the immune response to an exercise challenge (EC) and (b) a pilot trial assessing the neuro-immune-endocrine change induced by acute decreasing by half the usual physical activity level. A total of 46 participants (26 females), median aged 25 years were included. Of those 39-completed protocol, including overweight, physical active and inactive and participants with asthma. There were no differences in the EC between interventions. Dietary factors and physical activity were closely monitored during interventions and kept si...Continue Reading

Methods Mentioned

BETA
flow cytometry
ELISA
PCR
enzyme-linked immunosorvent assay

Clinical Trials Mentioned

NCT02027675

Software Mentioned

STATA
Triturus
Food Processor
Excel
SPSS
BD Infinicyt
Food Processor Plus
WINSPIROPRO
Winspiro

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