Meal-stimulated gastrin release and calcitonin secretion

Journal of Endocrinological Investigation
M PedrazzoniM Passeri


In order to study the effects of a physiologic meal on calcitonin (CT) secretion we studied 6 normal male volunteers (aged 28-34 yr). Each subject was given, on two separate days, either a mixed meal or 200 ml of distilled water, in random order. Gastrin (G) was effectively stimulated by the meal (F = 8.82; p less than 0.001) and reached a peak (with an average 100% increase) 30 min after the end of the meal, slowly decreasing thereafter; no increase was seen after water ingestion. On the other hand, CT levels remained stable throughout the observation period on both occasions. Ionized and total calcium did not show significant variations either after the meal or after water ingestion. These findings suggest that G alone, at the concentrations usually reached after a physiologic meal, is unable to stimulate CT secretion, at least in the absence of calcium increases.


Jun 19, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J G Parthemore, L J Deftos
Dec 1, 1978·The American Journal of Digestive Diseases·C OwyangV L Go
Dec 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·J F Obie, C W Cooper
Nov 1, 1977·The Journal of Clinical Investigation·H Heath, G W Sizemore
Oct 15, 1975·Experientia·M PasseriE Palummeri
Feb 1, 1988·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M PedrazzoniE Palummeri
Aug 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D TiegsH Heath
Dec 1, 1973·Endocrinologia Japonica·T OyamaH Orimo
Nov 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J J Body, H Heath
Aug 1, 1981·European Journal of Clinical Investigation·G HeynenP Franchimont
Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R SethiG A Williams
Jan 29, 1981·The New England Journal of Medicine·L A Austin, H Heath

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