PMID: 7336139Jan 1, 1981Paper

Meal-stimulated secretin release in man: effect of acid and bile

Scandinavian Journal of Gastroenterology
O B Schaffalitzky de MuckadellH Worning

Abstract

Nine normal subjects were studied before and after intragastric instillation of a liquid meal. Gastric emptying rates of acid and pancreaticobiliary secretions were quantitated by means of a dilution indicator technique. A significant, positive correlation was found between load of acid to the duodenum and the concentration of secretin in plasma. No correlation was found between load of the bile acids and plasma secretin. The buffering capacity of gastric contents should be taken into account when fasting and postprandial periods are compared. Plasma secretin concentration remained low during the first postprandial hour. Maximum secretin concentrations and duodenal disappearance rate of acid was observed 1 1/2-2 h after instillation of the meal. In contrast, trypsin output was maximum within 10 min. The data support the concept that in man release of secretin is governed principally by the amount of hydrogen ions emptied into duodenum and indicate the importance of secretin in the late postprandial period, when the acidity of the gastric contents is high.

References

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Citations

May 1, 1985·Digestive Diseases and Sciences·S BondesenO B Schaffalitzky de Muckadell
Sep 1, 1982·Regulatory Peptides·O OektedalenO B Schaffalitzky de Muckadell
Mar 1, 1985·Regulatory Peptides·P M BellK G Alberti
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·J J Holst, P Schmidt
Jan 1, 1983·Acta Physiologica Scandinavica·H A El MunshidR Håkanson
Nov 22, 2013·World Journal of Gastroenterology : WJG·Björn Lindkvist
Oct 1, 1988·Digestive Diseases and Sciences·J ChristiansenO B Schaffalitzky de Muckadell
May 1, 1989·Scandinavian Journal of Gastroenterology·J OlsenJ Christiansen
May 1, 1993·Scandinavian Journal of Gastroenterology·R L Riepl, P Lehnert
Jul 1, 1993·Scandinavian Journal of Gastroenterology·O OlsenP Berlac
Mar 1, 1997·Scandinavian Journal of Gastroenterology·M WøjdemannJ F Rehfeld
Aug 1, 1992·Scandinavian Journal of Gastroenterology·R L Riepl, P Lehnert
Jan 1, 1989·Scandinavian Journal of Gastroenterology·O OlsenP Cantor
Mar 17, 2000·Scandinavian Journal of Gastroenterology·M WøjdemannO Olsen
Jun 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J MiskowiakO B Schaffalitzky de Muckadell
Nov 21, 2001·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·O B Schaffalitzky de Muckadell
Aug 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J R HuertasF J Mataix
Sep 1, 1988·Scandinavian Journal of Gastroenterology·O OlsenH Worning
Jul 2, 1998·Acta Physiologica Scandinavica·S S SaetreO B Schaffalitzky de Muckadell
Feb 19, 1998·The American Journal of Gastroenterology·M WøjdemannO Olsen
Oct 16, 1999·Scandinavian Journal of Gastroenterology·C RiberO Olsen
Jul 15, 1999·The Journal of Clinical Endocrinology and Metabolism·M WøjdemannJ J Holst
Oct 1, 1990·European Journal of Clinical Investigation·G Adler, C Beglinger
Dec 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·O OlsenP Cantor

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