PMID: 3766762Oct 1, 1986Paper

Mean circulatory filling pressure: potential problems with measurement

The American Journal of Physiology
M L GaddisC L MacAnespie

Abstract

Three experimental series using 22 acutely splenectomized mongrel dogs were completed to 1) compare fibrillation (Fib) and acetylcholine (ACh) injection as methods to stop the heart for the mean circulatory filling pressure (Pmcf) maneuver, and 2) test whether Pmcf equals portal venous pressure 7 s after heart stoppage (Pportal7s). Blood volume changes of -10, -20, +10, or +20 ml/kg were imposed and Pmcf and Pportal measurements were obtained. Pportal7s and Pmcf were significantly different with volume depletion but were similar under control conditions. Pmcf with ACh and Pmcf with Fib were significantly different only after a volume change of -20 ml/kg. However, severe pulmonary congestion and atelectasis were detected in animals where Ach was used to stop the heart. In some cases (with injection directly into the pulmonary artery) the damage was severe enough to cause irreversible arterial hypoxia. Thus we conclude that the repeated use of ACh may exert a detrimental influence on pulmonary function, changing the physiological status of the experimental animal. Also, the central venous pressure at 7 s of heart stoppage (Pcv7s) is not a fully accurate estimate of the true mean circulatory filling pressure during the Pmcf maneuv...Continue Reading

Citations

Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L MacéJ Y Neveux
Jul 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·David BergerJukka Takala
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adrienne Robyn MinerickKenneth R Olson

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