Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers

Alcoholism, Clinical and Experimental Research
Masako YokoyamaHaruo Nakamura

Abstract

Increased mean corpuscular volume (MCV) is common in alcohol abusers and alcoholics. MCV is higher in Japanese heavy drinkers with inactive aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/2*2 than among those with active ALDH2 encoded by ALDH2*1/2*1. Inactive ALDH2 dramatically increases blood acetaldehyde levels after alcohol intake. Because moderate and heavy drinkers with ALDH2*1/2*2 have very high risks for esophageal cancer, MCV might serve as an indicator of these high-risk drinkers. In this investigation of the association of red cell values with the ALDH2 genotype and possible confounding factors, the drinking, smoking, and dietary habits reported on a structured questionnaire by 163 Japanese working men were subjected to multivariate analyses. Aging, lower body mass index (BMI), more alcohol consumption, and more smoking were positively associated with increased MCV. Among moderate to heavy drinkers (>or=9 units/week; 1 unit = 22 g of ethanol), both MCV and mean corpuscular hemoglobin were higher and the red cell count was lower in those with ADLH2*1/2*2 than in those with ALDH2*1/2*1. Multiple linear regression analysis after adjustment for age, BMI, and smoking revealed that a positive relationship between the am...Continue Reading

References

May 18, 2006·Journal of Gastroenterology and Hepatology·Mikihiro TsutsumiShujiro Takase
May 21, 2013·World Journal of Gastroenterology : WJG·Yu-Zhen ZhengJun-Ye Wang
Aug 10, 2005·Alcoholism, Clinical and Experimental Research·N HomannH Ishii
May 18, 2005·Alcoholism, Clinical and Experimental Research·Leimin SunN Homann
Sep 11, 2008·Alcoholism, Clinical and Experimental Research·Lise Lotte Nystrup HusemoenAllan Linneberg
Apr 4, 2006·The Journal of Laboratory and Clinical Medicine·Heidi KoivistoOnni Niemelä
Dec 15, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yang-Ming TsengJang-Hwa Lee

Citations

Oct 1, 1991·Alcoholism, Clinical and Experimental Research·K SeppäM Saarni
Feb 1, 1991·Alcoholism, Clinical and Experimental Research·N EnomotoA Takada
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W F Bosron, T K Li
Jun 1, 1986·Alcoholism, Clinical and Experimental Research·S N Wickramasinghe, F Malik
Sep 30, 1982·The New England Journal of Medicine·R C MeagherJ L Spivak
Jan 1, 1993·Alcohol and Alcoholism. Supplement·S Harada, T Okubo
Apr 1, 1996·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F de WaardB J Slotboom
Sep 23, 1998·Carcinogenesis·Akira YokoyamaH Ishii
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·T Takeshita, K Morimoto
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·T L WallC L Ehlers

Related Concepts

Ethanol
Ethanol Measurement
Genetic Markers
Alcohol Abuse
ALDH2 gene
ALDH2 protein, human
Food Habits
Body Mass Index Procedure
Mean Corpuscular Hemoglobin Concentration Determination
Hemoglobin Measurement

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