Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis.

Journal of Thrombosis and Thrombolysis
Arzu CananSafiye Gürel

Abstract

The aim of this retrospective study was to evaluate the diagnostic value of mean platelet volume (MPV) and D-dimer for acute deep venous thromboembolism (DVT). Two hundred and fifty six patients who presented to the emergency or cardiovascular surgery department with suspected lower limb DVT were retrospectively recruited. Plasma levels of MPV, platelet count, and D-dimer were obtained and duplex sonography examination was performed for all patients. Eighty four patients had acute DVT which was diagnosed by duplex ultrasonography. MPV was significantly higher in patients with DVT than in those without DVT (p < 0.01). The mean MPV was 7.97 ± 17.8 and 7.58 ± 0.87 fL in patients with DVT and without DVT, respectively (p < 0.01). D-dimer was significantly higher in patients with DVT (p < 0.01). For all the patients, a positive MPV when the cut-off value was 7.3 fL, had 69.7 % sensitivity and 43.9 % specificity. D-dimer (with a cut-off value of 0.5 μg/mL) had 82.9 % sensitivity and 32.7 % specificity. In case of combination of MPV and D-dimer, the specificity exceeded (65.9 %) despite the reduction in sensitivity (59.2 %). Elevated MPV was found to be associated with acute DVT and high levels of MPV might increase the specificity of...Continue Reading

References

Apr 1, 1978·The American Journal of Medicine·S KarpatkinM Freedman
Jul 1, 1983·British Journal of Haematology·J F MartinD G Penington
May 20, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H S Khaira, J Mann
Aug 9, 2001·European Heart Journal·S KamathG Y Lip
Apr 3, 2002·Archives of Internal Medicine·James KellyBeverley J Hunt
Sep 25, 2004·The Journal of Emergency Medicine·Kaveh IlkhanipourSandra Kaplan
Dec 8, 2004·Annals of Internal Medicine·Suman W RathbunGary E Raskob
Jul 22, 2005·International Journal of Clinical Practice·E CobanF Akcit
Jul 27, 2005·American Journal of Hematology·Satoshi OtaTakeshi Nakano
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·J A Heit
Dec 17, 2005·AJR. American Journal of Roentgenology·Rathan M SubramaniamRobin Allen
Jun 6, 2009·Journal of Thrombosis and Haemostasis : JTH·S K BraekkanJ B Hansen
Jul 14, 2009·Journal of Clinical Psychopharmacology·Ahmet Ataoglu, Fatih Canan
Aug 21, 2009·Journal of Thrombosis and Haemostasis : JTH·S G ChuJ S Berger
Nov 24, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mehmet GulcanMustafa Kayan

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Citations

Jun 9, 2012·Journal of Thrombosis and Thrombolysis·Ercan Varol
Sep 3, 2013·International Journal of Cardiology·Satoshi Kurisu, Yasuki Kihara
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Cigdem Usul AfsarSebnem Izmir Guner
Apr 12, 2013·Platelets·Emine Nur RifaiogluAsena Cigdem Dogramaci
Apr 25, 2015·The American Journal of Emergency Medicine·Jianqiang HuangPing Chen
Apr 27, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Anna Dietrich-Muszalska, Barbara Wachowicz
Sep 18, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Benjamin JacobsThomas Wakefield
Jun 18, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chaoqin MaoCheng Fan

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