Mean platelet volume as a predictive marker for venous thromboembolism in patients treated for Hodgkin lymphoma

Oncotarget
Joanna Rupa-MatysekMieczysław Komarnicki

Abstract

Mean platelet volume (MPV) is reported to be associated with the risk of venous thromboembolism (VTE) and mortality in patients with cancer. We sought to determine the association of MPV with symptomatic VTE occurrence in patients treated for newly diagnosed Hodgkin lymphoma (HL) and their outcomes. We retrospectively studied 167 consecutive adult patients treated with HL. During first-line treatment 12 (7.2%) patients developed VTE and 14 (8%) died within the observation period. The pre-chemotherapy values of MPV were significantly lower in VTE patients than those without (p=0.0343). Patients with MPV≤25th percentile (6.8 fl) had an increased risk of VTE occurrence (p=0.0244). In multivariate analysis, MPV≤25th percentile (OR 2.21; 95%CI 1.07-4.57, p=0.033), advanced stage (OR 2.08; 95%CI 1.06-4.07, p=0.033) and bulky disease (OR 2.23; 95%CI 1.16-4.31, p=0.016) were significant factors for developing VTE. Only the impact of MPV≤25th percentile on VTE-free survival rates was found. VTE occurred in 43% (n=3) of the high-risk patients of the Thrombosis Lymphoma (ThroLy) score and in 17% (n=2) of the high-risk of the Khorana Risk Score (KRS). Neither the KRS nor the ThroLy score could identify patients at a high risk of VTE with a...Continue Reading

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Citations

Dec 31, 2019·Disease Markers·Katarzyna Brzeźniakiewicz-JanusLidia Gil
Jan 18, 2019·Cancers·Silvia RiondinoFiorella Guadagni

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

PROTECHT
ThroLy
Vienna CATS
STATISTICA Medical Package
CONKO
STATISTICA

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