Mean platelet volume is increased in chronic hepatitis C patients with advanced fibrosis

Clinics and Research in Hepatology and Gastroenterology
Tugrul PurnakOsman Yuksel

Abstract

Liver biopsy is the gold standard procedure for documenting liver damage in chronic hepatitis C (CHC), as for many other chronic liver diseases. Mean platelet volume (MPV) is a laboratory marker obtained from complete blood count (CBC) analysers in routine clinical practice. The goal of the present study was to evaluate whether MPV would be useful in predicting liver histologic severity in CHC. A total of 59 patients with CHC and 25 control subjects were recruited into the present study. There were 26 men and 33 women in the CHC group and 12 men and 13 women in the control group. MPV was recorded at the time of admission. The clinical characteristics of CHC patients, including demographics, laboratory and liver biopsy findings, were reviewed. A statistically significant increase in MPV values was observed in CHC patients (8.54 ± 0.63 fL) compared to healthy controls (7.65 ± 0.42 fL) (P < 0.001). Moreover, MPV values were significantly higher among patients with advanced fibrosis as compared to those with mild fibrosis (8.99 ± 0.57 fL vs. 8.19 ± 0.50 fL P < 0.001). Receiver operator characteristic (ROC) curve analysis suggested that the optimum cut-off point for MPV value in advanced fibrosis was 8.75 fL. (Sensitivity: 80.8%, sp...Continue Reading

References

Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Feb 28, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·K MimidisG Kartalis
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Jan 13, 2010·Rheumatology International·Armen Yuri GasparyanGeorge D Kitas
Feb 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Füsun Mayda-DomaçMustafa Yilmaz
Nov 3, 2010·Digestion·Alexander WreeAli Canbay
Jan 21, 2011·Current Pharmaceutical Design·Armen Yuri GasparyanGeorge D Kitas
May 14, 2011·Journal of Clinical Laboratory Analysis·Fuat EkizSeyfettin Köklü
Jun 18, 2011·Upsala Journal of Medical Sciences·Tugrul PurnakEmin Altiparmak
Nov 18, 2011·Clinics and Research in Hepatology and Gastroenterology·Yavuz BeyazitMehmet Ibis
Jan 5, 2012·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Levent KorkmazSükrü Celik

❮ Previous
Next ❯

Citations

Nov 2, 2013·Clinics and Research in Hepatology and Gastroenterology·Tekin TasHayrettin Akdeniz
Mar 4, 2014·Multidisciplinary Respiratory Medicine·Gulsah GunluogluSedat Altin
Jan 21, 2014·Wiener klinische Wochenschrift·Ergenekon KaragözVedat Turhan
Jun 24, 2014·Clinics and Research in Hepatology and Gastroenterology·Ergenekon Karagöz, Alpaslan Tanoglu
Dec 25, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo G GianniniVincenzo Savarino
Mar 26, 2015·Platelets·Ahmet SertSukru Arslan
Jul 11, 2013·Upsala Journal of Medical Sciences·Tugrul PurnakEmin Altiparmak
Oct 8, 2016·Journal of Health, Population, and Nutrition·Fatih AkınŞükrü Arslan
Jan 30, 2019·European Journal of Gastroenterology & Hepatology·Ahmed Abdel-RazikMahmoud El-Bendary
Oct 17, 2017·European Journal of Gastroenterology & Hepatology·Ahmed Abdel-RazikMostafa Abdelsalam
Nov 13, 2019·European Journal of Gastroenterology & Hepatology·Hasan Tahsin Gozdas, Nevin Ince
Nov 21, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tugrul PurnakErsan Ozaslan
Aug 27, 2015·European Journal of Gastroenterology & Hepatology·Mustafa TahtaciOsman Ersoy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.