Mean red cell volume in normal, anemic, small, trisomic and triploid fetuses

Fetal Therapy
K H NicolaidesA J Bellingham

Abstract

A reference range for fetal mean red cell volume (MCV) with gestation was established from the study of samples obtained by cordocentesis from 466 pregnancies undergoing prenatal diagnosis for non-erythrocyte abnormalities. The mean MCV decreased from 145 fl at 16 weeks to 113 fl at 36 weeks of gestation. Alterations in MCV were investigated in 154 red cell isoimmunized and 231 small for gestational age (SGA) fetuses. In red cell isoimmunization, significant macrocytosis was observed when the fetal hemoglobin concentration deficit was greater than or equal to 6 g/dl. In the chromosomally normal SGA fetuses (n = 178), the MCV was increased and the magnitude of macrocytosis was significantly associated with gestation and the degrees of fetal 'smallness' and fetal hypoxemia. However, the most severely macrocytotic SGA fetuses were those with triploidy (n = 22). In the SGA fetuses with other chromosomal defects (n = 31), the MCV was higher than the controls but lower than that of the chromosomally normal hypoxemic fetuses. It is suggested that in severe growth retardation there is developmental delay in the normal evolution from hepatic to medullary hemopoiesis and this is most marked in triploid fetuses. In contrast, in red cell i...Continue Reading

Citations

Apr 1, 1992·American Journal of Obstetrics and Gynecology·D R SalvesenK H Nicolaides
Dec 1, 1996·Obstetrics and Gynecology·E JauniauxK H Nicolaides
Apr 1, 1992·Archives of Disease in Childhood·N P DaviesK H Nicolaides
Mar 1, 1997·Journal of Medical Genetics·J DeanA Smith
Apr 8, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanni PiantelliGiovanni Battista Nardelli
Jun 24, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R Al-MuftiK H Nicolaides
Apr 6, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R Al-MuftiK H Nicolaides
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Jan 16, 1998·Clinical Obstetrics and Gynecology·W B Kramer, C P Weiner

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