Means to increase the therapeutic efficiency of magnetic heating of tumors

Biomedizinische Technik. Biomedical Engineering
Melanie KetteringIngrid Hilger

Abstract

The treatment of tumors via hyperthermia has gained increased attention in the last years. Among the different modalities available so far, magnetic hyperthermia has the particular advantage of offering the possibility of depositing the heating source directly into the tumor. In this study, we summarized the present knowledge we gained on how to improve the therapeutic efficiency of magnetic hyperthermia using magnetic nanoparticles (MNPs), with particular consideration of the intratumoral infiltration of the magnetic material. We found that (1) MNPs will be mainly immobilized at the tumor area and that this aspect has to be considered when estimating the heating potential of MNPs, (2) the intratumoral distribution patterns via slow infiltration might well be modulated by specific MNP coating and magnetic targeting, (3) imaging of the nanoparticle depositions within the tumor might allow to correct the distribution pattern via multiple applications, (4) multiple therapeutic sessions are feasible because MNPs are not delivered from the tumor site during the heating process, (5) the utilization of MNPs that internalize into cells will favor the production of intracellular heating spots rather than extracellular ones, (6) utilizat...Continue Reading

References

Feb 1, 1992·International Journal of Radiation Biology·E Dikomey, J Franzke
Feb 15, 1990·Analytical Biochemistry·Z Grabarek, J Gergely
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·T KojimaH Sezaki
Jul 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·W C Dewey
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Jul 6, 2002·Critical Reviews in Oncology/hematology·Bert HildebrandtHanno Riess
Jul 31, 2002·The Lancet Oncology·P WustP M Schlag
Feb 1, 2006·European Biophysics Journal : EBJ·Christoph AlexiouFritz G Parak
Jan 1, 1985·Journal of Pharmaceutical and Biomedical Analysis·J H BeijnenW J Underberg
Jan 11, 2007·Journal of Biomedical Optics·Marcus-René LisyIngrid Hilger
Jul 15, 2009·Acta Biomaterialia·S Purushotham, R V Ramanujan
Aug 8, 2009·Physics in Medicine and Biology·Melanie KetteringIngrid Hilger
Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pallab PradhanChristian Plank
Sep 22, 2012·Nanomedicine·Ingrid Hilger, Werner A Kaiser
May 15, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Rainer TietzeChristoph Alexiou
Jul 9, 2014·ACS Applied Materials & Interfaces·Antonio CervadoroPaolo Decuzzi

❮ Previous
Next ❯

Citations

Mar 13, 2016·International Journal of Pharmaceutics·María Muñoz de EscalonaJosé L Arias
Oct 2, 2015·Biomedizinische Technik. Biomedical Engineering·Lutz Trahms
Jun 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fátima Fernández-ÁlvarezJosé L Arias

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
atomic absorption spectrometry
xenografts
protein folding

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Ingrid Hilger
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Heidi DähringIngrid Hilger
© 2021 Meta ULC. All rights reserved