PMID: 6164764Jan 1, 1981Paper

Measles antibodies, kappa-lambda light chain distribution and immunoglobulins in serum, cerebrospinal fluid and brain of a patient affected with multiple sclerosis

Journal of Neurology
F BollengierG Clinet

Abstract

The serum, cerebrospinal (CSF) and brain of a patient (NAG) affected with multiple sclerosis (MS) were examined for measles antibodies with CF and HI techniques, and the kappa-lambda light chain ratios of all samples available were evaluated, kappa-lambda populations of the matched serum, CSF and brain specimens were all lambda-predominant and in agreement with each other; the light chain distribution f the brain specimens confirmed previous findings [3]. Only the serum immunoglobulins showed significant measles antibody titers, but slightly increased measles antibody titers were also observed in ventricular plaques. The amount of immunoglobulin G (IgG) synthesized per day by the central nervous system (CNS) was estimated. The IgG synthesis in CNS NAG (11.6 mg/day) was above the upper limit of the normal range (3.3 mg/day), but apparently there was no positive correlation between the intracerebral IgG synthesis and specific anti-measles IgG.

References

Sep 1, 1975·The Journal of Experimental Zoology·R ArkingM Schubiger
Jul 1, 1975·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F BollengierW Henrotin
Jan 1, 1969·Archiv für die gesamte Virusforschung·L ThiryA Lowenthal
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·H H KREUTZER, W H FENNIS
Sep 1, 1940·The Biochemical Journal·R A Kekwick

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Citations

Oct 1, 1984·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F BollengierP Delmotte
Apr 1, 1988·Journal of Neurochemistry·F Bollengier, A Mahler

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