Measles Outbreak in Pediatric Hematology and Oncology Patients in Shanghai, 2015

Chinese Medical Journal
Yan-Ling GeMei Zeng

Abstract

Despite substantial progress toward measles control are making in China, measles outbreaks in immunocompromised population still pose a challenge to interrupt endemic transmission. This study aimed to investigate the features of measles in pediatric hematology and oncology patients and explore the reasons behind the outbreak. We collected demographic, epidemiological, and clinical data of immunocompromised measles children. All suspected measles cases were laboratory-confirmed based on the presence of measles IgM and/or identification of measles RNA. The clinical data were statistically analyzed by t-test for continuous variables and Fisher's exact test for categorical variables. From March 9 to July 25 in 2015, a total of 23 children with malignancies and post hematopoietic stem cell transplantation (post-HSCT) were notified to develop measles in Shanghai. Of these 23 patients with the median age of 5.5 years (range: 11 months-14 years), 20 (87.0%) had received 1-3 doses of measles vaccine previously; all patients had fever with the median fever duration of 8 days; 21 (91.3%) had cough; 18 (78.3%) had rash; 13 (56.5%) had Koplik's spot; 13 (56.5%) had complications including pneumonia and acute liver failure; and five (21.7%) ...Continue Reading

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Citations

Apr 18, 2019·The New England Journal of Medicine·Catharine I PaulesAnthony S Fauci
Nov 28, 2019·International Journal of Environmental Research and Public Health·Ka Chun ChongHanqing He
May 5, 2020·Frontiers in Immunology·Claudia Bettoni da Cunha-RiehmMeinolf Suttorp
Feb 12, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christine RobinCatherine Cordonnier
Jul 29, 2021·JAMA Network Open·Sara R MarquisElizabeth M Krantz
Aug 29, 2021·Journal of the National Cancer Institute·Astha ThakkarJeremy L Warner

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA
PCR
X-ray

Software Mentioned

Stata

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