PMID: 11320764Apr 26, 2001Paper

Measles sero-surveillance during mass immunisation campaign in Malawi

East African Medical Journal
M TakechiJ Michongwe

Abstract

To determine age-specific measles antibody prevalence and serological response to vaccination during the first mass campaign against measles in Malawi. Cross-sectional study using a questionnaire and a serological particle agglutination (PA) test. Two health centres in Salima district, central Malawi during the national measles immunisation week, 1998. Two hundred forty six under-five year old children. Seventy four per cent of enrolled children (95% confidence interval, 69-80%) were measles PA antibody positive at the vaccination. The antibody positive rate was 17.4% in children aged 8-12 months and gradually increased up to 90% by four years-old, while the age-specific geometric mean titers (GMTs) in 48-59 months-old group were significantly lower than those in 24-35 months-old group, suggesting antibody waning after previous vaccination (p = 0.0047). Two hundred and thirty follow up specimens were obtained eight weeks after the vaccination. The sero-conversion rate was 100% in 58 children sero-negative at the vaccination and the GMTs in 172 children seropositive at the vaccination were significantly increased (p < 0.001). These results indicated that the first national measles immunisation campaign successfully immunised the...Continue Reading

Citations

Jun 17, 2011·The Journal of Infectious Diseases·Jiatong ZhuoJian Zhang

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