Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection

The Journal of Infectious Diseases
Samantha BrandlerFrédéric Tangy

Abstract

West Nile virus (WNV) is a mosquito-borne flavivirus that emerged in North America and caused numerous cases of human encephalitis, thus urging the development of a vaccine. We previously demonstrated the efficacy of a recombinant measles vaccine (MV) expressing the secreted form of the envelope glycoprotein from WNV to prevent WNV encephalitis in mice. In the present study, we investigated the capacity of this vaccine candidate to control WNV infection in a primate model. We first established experimental WNV infection of squirrel monkeys (Saimiri sciureus). A high titer of virus was detected in plasma on day 2 after infection, and viremia persisted for 5 days. A single immunization of recombinant MV-WNV vaccine elicited anti-WNV neutralizing antibodies that strongly reduced WNV viremia at challenge. This study demonstrates for the first time the capacity of a recombinant live attenuated measles vector to protect nonhuman primates from a heterologous infectious challenge.

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Citations

Oct 3, 2013·Viruses·Samantha Brandler, Frederic Tangy
Feb 27, 2014·Molecular Biotechnology·Indulis CielensRegina Renhofa
Nov 19, 2014·Future Microbiology·Sebastian Ulbert, Sofia E Magnusson
Dec 4, 2015·Human Vaccines & Immunotherapeutics·Aline BaldoPhilippe Herman
Apr 19, 2015·Stem Cell Research & Therapy·Christopher B DriscollPatricia Devaux
Oct 29, 2013·Vaccine·Richard StebbingsGérald Voss
Apr 8, 2014·Vaccine·Hubert BuczkowskiAshley C Banyard
Jul 6, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Juliane W SchottAxel Schambach
Feb 9, 2019·Human Vaccines & Immunotherapeutics·Arturo Reyes-Sandoval
Jan 3, 2019·Expert Review of Vaccines·Christiane GerkeFrédéric Tangy
Apr 3, 2014·Expert Review of Vaccines·Ian J Amanna, Mark K Slifka
Dec 7, 2016·The Journal of Infectious Diseases·Katrin Ramsauer, Frédéric Tangy
Jul 16, 2017·Virus Genes·Michael D Mühlebach
Mar 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mijia LuJianrong Li

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