Measles virus genome in infections of the central nervous system

The Journal of Infectious Diseases
A T HaaseC J Gibbs

Abstract

The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction plays an important role in persistence of measles virus and the slow evolution of disease in these and other slow infections.

Citations

Jan 1, 1985·Progress in Neurobiology·M B RosenbergX O Breakefield
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A T HaaseW Tourtellotte
Mar 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·C L LancellottiM I Duarte
Mar 1, 1989·Annals of Neurology·H NishinoB K Rima
Jan 1, 1984·Annals of the New York Academy of Sciences·A T HaaseK Warren
Jun 6, 1994·Annals of the New York Academy of Sciences·N NathansonF Gonzalez-Scarano

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