Nov 2, 2019

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

Science
Michael J MinaStephen J Elledge

Abstract

Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.

  • References43
  • Citations17

References

  • References43
  • Citations17

Citations

Mentioned in this Paper

Measles virus
Virus Diseases
Magnetic Resonance Imaging
Vaccination
Mumps
Blood
Negative Regulation of Immune Cell Activation
Epidemiologic Studies
Humoral Immune Response
Macaca mulatta

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