PMID: 9445022Jan 28, 1998Paper

Measles viruses with altered envelope protein cytoplasmic tails gain cell fusion competence

Journal of Virology
T CathomenR Cattaneo

Abstract

The cytoplasmic tail of the measles virus (MV) fusion (F) protein is often altered in viruses which spread through the brain of patients suffering from subacute sclerosing panencephalitis (SSPE). We transferred the coding regions of F tails from SSPE viruses in an MV genomic cDNA. Similarly, we constructed and transferred mutated tail-encoding regions of the other viral glycoprotein hemagglutinin (H) gene. From the mutated genomic cDNAs, we achieved rescue of viruses that harbor different alterations of the F tail, deletions in the membrane-distal half of the H tail, and combinations of these mutations. Viruses with alterations in any of the tails spread rapidly through the monolayer via enhanced cell-cell fusion. Double-tail mutants had even higher fusion competence but slightly decreased infectivity. Analysis of the protein composition of released mutant viral particles indicated that the tails are necessary for accurate virus envelope assembly and suggested a direct F tail-matrix (M) protein interaction. Since even tail-altered glycoproteins colocalized with M protein in intracellular patches, additional interactions may exist. We conclude that in MV infections, including SSPE, the glycoprotein tails are involved not only in...Continue Reading

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Citations

Oct 12, 2000·Journal of Virology·U SchneiderR Cattaneo
Apr 5, 2002·Journal of Virology·Veronika von Messling, Roberto Cattaneo
May 7, 2002·Journal of Virology·Markus U EhrengruberHussein Y Naim
Jul 5, 2002·Journal of Virology·Urs SchneiderRoberto Cattaneo
Sep 13, 2003·Journal of Virology·Veronika von Messling, Roberto Cattaneo
Nov 28, 2007·Uirusu·Takashi Irie, Takemasa Sakaguchi
Jul 16, 2008·Journal of Biomolecular Screening·Jeong-Joong YoonRichard K Plemper
Jul 10, 2009·Journal of Virology·Michael ZinkeJürgen Schneider-Schaulies
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lassi LiljeroosSarah J Butcher
Jun 17, 2011·The Journal of Infectious Diseases·Bettina BankampPaul A Rota
Dec 4, 2012·Viruses·Dominique J BurriAntonella Pasquato
Nov 7, 2019·Viruses·Marion FerrenCyrille Mathieu
Oct 22, 2002·The Journal of General Virology·Gabriele NeumannYoshihiro Kawaoka
Apr 23, 2002·Journal of Virology·Richard K PlemperRoberto Cattaneo
Sep 16, 2004·The Journal of Gene Medicine·Jie ZhangStephen J Russell
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Jul 22, 2005·The Journal of General Virology·Martin LudlowW Paul Duprex
Aug 17, 2004·Journal of Virology·Tsanan GiroglouDorothee von Laer
Jul 11, 2009·The Journal of International Medical Research·C YilmazH Caksen
Oct 6, 2009·The Journal of Biological Chemistry·Ana Shulla, Tom Gallagher

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