Measured Changes in Limbal Strain During Simulated Sleep in Face Down Position Using an Instrumented Contact Lens in Healthy Adults and Adults With Glaucoma

JAMA Ophthalmology
Alison FlatauHarry A Quigley

Abstract

Eyes of patients with glaucoma may be damaged during sleep. To measure strains in glaucoma eyes and control eyes produced by mechanical force or deformation of the eye from contact when one side of the face rests against a pillow. This study took place in a clinic-based setting among 22 patients with glaucoma and 11 age-matched controls. The research was conducted at Wilmer Eye Institute between February 4, 2014, and December 2, 2014. Data analysis was done from June 3, 2014, to June 30, 2015. We used a contact lens sensor (CLS) to measure change in limbal strain associated with placing one side of the face down (FD) on a pillow in simulated sleep. Baseline intraocular pressure (IOP) was measured with a tonometer. The CLS data were collected every 5 minutes during intervals of up to 60 minutes in various positions, including sitting, lateral decubitus, FD (with the CLS-instrumented eye toward the pillow), and supine. Measured changes in limbal strain were related to estimated changes in IOP and to modeled strain produced by changes in IOP. Among 22 patients with glaucoma and 11 controls, 17 were female. The mean age for the glaucoma group was 62.6 years, while the mean age for the control group was 61.4 years (P = .68). Baselin...Continue Reading

Citations

Oct 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Idan HechtZvia Burgansky-Eliash
Sep 14, 2018·Cornea·Hidenaga Kobashi, Joseph B Ciolino
Oct 8, 2019·Current Opinion in Ophthalmology·Kevin KaplowitzRobert Honkanen
Oct 10, 2018·Acta Ophthalmologica·Ida A van MeursHans G Lemij
Oct 24, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Xiang ChenWen Xu

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