Abstract
Small-dense low density lipoprotein (sdLDL) is increasingly viewed as a marker for evaluating atherogenic risk, however its clinical uptake is hampered by the cumbersomeness of available methods. Consequently, a number of alternative methods for the estimation of sdLDL have been developed and none have been tested in a population from Africa. We evaluated an equation to estimate sdLDL-C from classic lipid parameters in South Africans. This is a cross-sectional study involving 1550 participants in which direct measurement of sdLDL in 237 participants was performed using a homogeneous enzymatic assay. Their mean age (standard deviation, SD) was 54.2 (14.7) years. 156 (65.8%) were normotolerant, 29 (12.2%) prediabetes, 17 (7.2%) screen detected diabetes and 35 (14.8%) known diabetes. Measured sdLDL values ranged from 0.17 to 3.39 versus-1.85 to 2.52 mmol/L calculated sdLDL. There was a significant positive correlation between the two measurements with a Pearson correlation coefficient of 0.659 (95%CI: 0.581-0.726). In a regression model, the adjusted R2 was 0.440 after adding age, 0.441 after further adding gender, then 0.443 with dysglycemia and lastly 0.447 upon adding body mass index. With the exception of HDL-cholesterol level...Continue Reading
References
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Oct 1, 1994·Current Opinion in Lipidology·R M Krauss
Aug 5, 1998·Atherosclerosis·Y HattoriY Harano
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·J ChalmersT Clark
Dec 18, 2002·Acta Diabetologica·A M WägnerA Pérez
Nov 6, 2010·Clinical Chemistry·Yasuki ItoTsutomu Hirano
Jun 21, 2011·American Journal of Clinical Pathology·Pornpen SrisawasdiMartin H Kroll
Feb 15, 2012·Cardiovascular Journal of Africa·T E MatshaR T Erasmus
Sep 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Satoshi Hirayama, Takashi Miida
Nov 3, 2012·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·Rajiv Timothy ErasmusTandi Edith Matsha
Dec 4, 2012·Diabetes Research and Clinical Practice·T E MatshaR T Erasmus
Mar 20, 2013·Nutrients·Dragana NikolicManfredi Rizzo
May 15, 2013·American Journal of Clinical Pathology·Yonggeun ChoKyunghwa Han
Jul 19, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Julio Lara-RiegosPatricia Lozano-Zarain
Feb 22, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Ron C HoogeveenChristie M Ballantyne
May 21, 2014·Journal of Diabetes Investigation·Sunghwan SuhMoon-Kyu Lee
Jul 23, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Koji KikkawaMasami Murakami
Apr 22, 2017·Indian Journal of Clinical Biochemistry : IJCB·Pravin K GoelChandra Mohan Pandey