PMID: 12761466May 23, 2003Paper

Measurement and application of arterial stiffness in clinical research: focus on new methodologies and diabetes mellitus

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Richard J Woodman, Gerald F Watts

Abstract

The excess risk of cardiovascular disease in patients with Type 2 diabetes mellitus remains largely unexplained. Arterial stiffness, an early feature of diabetic vasculopathy involving several mechanisms, results in impaired arterial compliance, and has recently been proposed as a powerful independent predictor of cardiovascular disease. Increased arterial stiffness can contribute to the development and progression of hypertension, left ventricular hypertrophy and dysfunction, and to decreased myocardial perfusion, all of which are highly prevalent in Type 2 diabetes mellitus. Large artery stiffening has been demonstrated in Type 2 diabetes using several different methods including measurement of central pulse wave velocity, or estimation of aortic compliance, a technically demanding technique requiring the simultaneous measurement of stroke volume and diastolic pressure decay. Increased arterial stiffness of smaller arteries is also an important contributor to systemic arterial stiffness and cardiovascular risk. Increasing demand by clinical researchers for measurement of arterial stiffness has led to the development and commercial availability of highly practicable techniques. These new techniques, which utilise different asp...Continue Reading

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