Measurement and prediction of thermal behavior and acute assessment of injury in a pig model of renal cryosurgery

Journal of Endourology
Franz SchmidlinJ C Bischof

Abstract

To analyze in vivo end temperatures and histologic injury in a standardized cryo-iceball using a porcine kidney model in order to establish the threshold temperature for tissue ablation. To evaluate the ability to predict end temperatures using a thermal finite element model. A single freeze/thaw cryolesion was created in five pig kidneys and the temperature history recorded. End temperature was calculated using a thermal finite element model. The threshold temperature for tissue injury was established by directly correlating end temperature and histologic injury. Reproducible geometry and temperature profiles of the cryo-iceball were found. End temperature could be accurately predicted through thermal modeling, and correlation with histologic injury revealed a threshold temperature of -16.1 degrees C for complete tissue ablation. Thermal modeling may accurately predict end temperature within a cryo-iceball. Provided threshold temperatures for tissue destruction are known, modeling may become a powerful tool in cryosurgery, improving the assessment of damage in normal and malignant tissue.

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Citations

Sep 7, 2002·Urology·Nathan E Hoffmann, John C Bischof
Jan 30, 2003·The Journal of the American Association of Gynecologic Laparoscopists·Christopher C RuppJames E Coad
Jan 9, 2007·Journal of Endourology·Brian K AugeThomas J Polascik
May 4, 2010·Journal of Endourology·Jennifer L Young, Ralph V Clayman
May 10, 2005·The Journal of Urology·James H BrashearsThomas J Polascik
Mar 23, 2007·AJR. American Journal of Roentgenology·Sompol PermpongkosolStephen B Solomon
May 24, 2011·The Journal of Urology·Jennifer Lee YoungRalph Victor Clayman
Dec 22, 2009·The Journal of Urology·Jennifer L YoungRalph V Clayman
Jun 20, 2008·Journal of Biomechanics·Jessica E GoetzThomas D Brown
Mar 1, 2007·Journal of Vascular and Interventional Radiology : JVIR·Sompol PermpongkosolStephen B Solomon
Jan 25, 2017·Journal of Endourology·Jeremy W MartinRalph V Clayman
May 27, 2004·Technology in Cancer Research & Treatment·Robert J GriffinJohn C Bischof
Jul 23, 2008·Technology in Cancer Research & Treatment·Patricia W T BeemsterHessel Wijkstra

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