Measurement characteristics of a new rapid anti-CCP2 test compared to the anti-CCP2 ELISA

Scandinavian Journal of Rheumatology
G F SnijdersF H J van den Hoogen

Abstract

Anti-cyclic citrullinated peptide (CCP)2 antibody status is an important diagnostic tool in the work-up of undifferentiated arthritis (UA)/early rheumatoid arthritis (RA) but the results of the enzyme-linked immunosorbent assay (ELISA) are only available a few days after the test. The aim of this study was to assess the measurement characteristics of a rapid anti-CCP2 test compared to the usual anti-CCP2 ELISA test. In the first phase, rapid anti-CCP2 (CCPoint) tests were performed in capillary blood obtained by finger puncture (CAP), in venous blood from a clot tube (CLOT) and in serum (SERUM) in consenting RA patients. Anti-CCP2 measured in serum using the anti-CCP2 ELISA (ELISA) was set as the gold standard (reference). In the second phase of the study, specificity versus RA was confirmed in consenting non-RA patients and healthy controls. The anti-CCP2 results were negative (no visible line or anti-CCP2<25 U/mL) or positive (visible line or anti-CCP2> or =25 U/mL). A total of 880 subjects (109 RA patients, 351 non-RA patients and 420 healthy controls) were enrolled in this study. For the RA patients, 5%, 15%, and 1% of CAP, CLOT and SERUM tests, respectively, were inconclusive. The sensitivity and specificity of CAP compare...Continue Reading

Citations

Oct 31, 2009·Arthritis and Rheumatism·Rohit AggarwalKaren H Costenbader
Dec 17, 2008·Annals of the New York Academy of Sciences·Walther J van VenrooijGer J M Pruijn
Jul 30, 2016·Immunologic Research·Gisele Zandman-GoddardNancy Agmon-Levin
Apr 21, 2020·Evolution; International Journal of Organic Evolution·Roger Maia D LedoGuarino R Colli
Jul 7, 2009·Deutsches Ärzteblatt International·Karl EgererGerd-Rüdiger Burmester

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