Measurement of airway resistance in anesthetized and paralyzed subjects: proposal for evaluation of K1 values

Journal of Anesthesia
T SakaiM Takaori

Abstract

The effects of lung volume and respiratory airflow on airway resistance were studied in five anesthetized and paralyzed patients. Airway resistance measured during the inspiratory phase with intermittent constant airflow inflations decreased in inverse correlationship to increases in lung volume. Airway resistance measured during the expiratory phase with an airway interruption technique, on the other hand, increased with a linear relationship to the expiratory airflow as expressed by a function of Y = K(1) + K(2)X. K(1), calculated from the values of airway resistance corresponding to three different airflows, was unaffected by intentional expiratory resistance loading. Thus, simultaneously with the measurement of airway resistance by this method, expiratory gas sampling with a Douglas bag can be done if necessary. Since the K(2) value of the endotracheal tube used in this study (Portex((R)) I.D. 8 mm, length 26 cm) was quite high (5.0 cmH(2)O.1(-2).sec(2)), depending on the airflow, the presence of the endotracheal tube strongly affected the measurement of airway resistance during general anesthesia. K(1) measured by the above method, however, may be considered as the best way to evaluate the lower airway resistance independe...Continue Reading

References

Jun 1, 1985·Journal of Applied Physiology·A RossiJ Milic-Emili
Nov 1, 1966·Journal of Applied Physiology·N A Bergman
Oct 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P K BehrakisJ Milic-Emili
Mar 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S B GottfriedJ Milic-Emili
Jan 1, 1954·Journal of Applied Physiology·J MEAD, J L WHITTENBERGER
Jul 1, 1959·The Journal of Clinical Investigation·J A CLEMENTSJ O ELAM
Mar 1, 1961·Journal of Applied Physiology·R E HYATT, R E WILCOX
Jul 1, 1964·Journal of Applied Physiology·B G FERRISL H OPIE
Nov 1, 1964·Journal of Applied Physiology·R W BLIDEW S SPICER

❮ Previous
Next ❯

Citations

May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H Yoshida, M Takaori

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.