PMID: 9183492May 1, 1997Paper

Measurement of albumin and low molecular weight proteins in the urine of newborn infants using a cotton wool ball collection method

Acta Paediatrica
J M FellC P Price

Abstract

The aim of this study was to investigate the inter-relationship between urinary excretion of alpha-1-microglobulin (A1M), retinol-binding protein (RBP) and albumin in term and premature neonates, with urine collected into cotton wool balls and extracted by a novel method. Sixty-four infants were studied on the first day of life; 26 had been born at term (37-42 weeks gestation) and 38 prematurely (24-28 weeks n = 16, 29-36 weeks n = 22). Urine collected into cotton wool balls was analysed following a new detergent extraction method, which resulted in a recovery rate of 94-107% for albumin. A1M, RBP and creatinine. Urinary protein excretion, expressed as a ratio to urinary creatinine, decreased significantly with increasing gestational age (24-28 weeks, 29-36 weeks, 37-42 weeks: albumin:creatinine ratio mg/mmol mean 96.9, 31.7, 19.3; A1M:creatinine ratio mg/mmol mean 99.3, 37.0, 7.8; RBP:creatinine ratio mg/mmol mean 16.2, 3.8, and < 0.01, below the limit of detection, respectively). When results were corrected for birthweight, this gestation-associated effect was still present for A1M and RBP, but not for albumin. In premature infants there was a significant positive correlation between A1M:creatinine ratio and RBP:creatinine ra...Continue Reading

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Citations

Dec 3, 2008·European Journal of Clinical Pharmacology·R AntonucciV Fanos
Aug 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Britta NaglFlorian J Schweigert
Oct 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mariangela LonginiEnrico Brunoldi
Jan 10, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yanhong LiXing Feng
Jul 4, 2006·Wiener klinische Wochenschrift·Milena TreiberMaksimiljan Gorenjak
Jan 30, 2014·Bioanalysis·Nicoletta IacovidouVassilios Fanos
May 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ahmet Taner ElmasSevcan Ipek
Sep 30, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Luigi AtzoriVassilios Fanos
Oct 6, 2012·Pediatric Clinics of North America·Aggeliki SyggelouVassilios Fanos
Aug 30, 2008·Drug Discovery Today·Saskia N de WildtGideon Koren
Oct 18, 2015·European Journal of Pediatrics·Bettina SchmiedchenFlorian J Schweigert
Mar 15, 2002·Journal of Chemotherapy·L CataldiUNKNOWN Neonatal Nephrology Study Group of the Italian Society of Neonatology
Jun 17, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Chahrazed El HamelVincent Guigonis
Aug 26, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Cristina AisaGian Carlo Di Renzo
Mar 24, 2011·Reproductive Sciences·Lina GubhajuM Jane Black
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Alexandre Rodrigo CoelhoElisa Yoko Hirooka
Jun 6, 2014·American Journal of Physiology. Renal Physiology·Lina GubhajuM Jane Black
Jan 5, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Laure PonthierChahrazed El Hamel

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