Measurement of brain atrophy in subcortical vascular disease: a comparison of different approaches and the impact of ischaemic lesions

NeuroImage
Mike O'SullivanM Dichgans

Abstract

Measurement of brain atrophy has been proposed as a surrogate marker in MS and degenerative dementias. Although cerebral small vessel disease predominantly affects white and subcortical grey matter, recent data suggest that whole brain atrophy is also a good indicator of clinical and cognitive status in this disease. Automated methods to measure atrophy are available that are accurate and reproducible in disease-free brains. However, optimal methods in small vessel disease have not been established and the impact of ischaemic lesions on different techniques has not been explored systematically. In this study, three contrasting techniques -- Statistical Parametric Mapping 5 (SPM5), SIENAX and BrainVisa -- were applied to measure cross-sectional atrophy (brain parenchymal fraction or BPF) in a large (n=143) two-centre cohort of patients with CADASIL, a genetic model of small vessel disease. All three techniques showed similar sensitivity to trends in BPF associated with age and lesion load. No single technique was particularly vulnerable to error as a result of lesions. Provided major errors in registration were excluded by visual inspection, manual correction of segmentations had a negligible impact with mean errors of 0.41% for...Continue Reading

References

Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Jul 24, 2002·Brain : a Journal of Neurology·David H MillerAlan J Thompson
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 11, 2003·Journal of the Neurological Sciences·M A HorsfieldR Bakshi
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M O'SullivanH S Markus
Apr 13, 2004·Lancet·Nick C Fox, Jonathan M Schott
Oct 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·A M J MaclullichI J Deary
Oct 23, 2004·Stroke; a Journal of Cerebral Circulation·Wei Wen, Perminder S Sachdev
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jul 14, 2006·Neurobiology of Aging·Arlene M ManelliMary Jo LaDu
Jul 18, 2006·Brain : a Journal of Neurology·Anand ViswanathanHugues Chabriat
Jan 24, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Valerie M AndersonDavid H Miller
Apr 21, 2007·Stroke; a Journal of Cerebral Circulation·Eric JouventHugues Chabriat
Apr 25, 2007·Neurology·D H MillerUNKNOWN AFFIRM Investigators

❮ Previous
Next ❯

Citations

Nov 7, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Raffaella ValentiLeonardo Pantoni
Dec 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Antonio Giorgio, Nicola De Stefano
Sep 20, 2011·NeuroImage·Claudia Metzler-BaddeleyDerek K Jones
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Oct 18, 2011·Neurobiology of Aging·Eric JouventHugues Chabriat
May 14, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·François De GuioHugues Chabriat
Sep 4, 2010·Stroke; a Journal of Cerebral Circulation·Michelle L BakerUNKNOWN Multi-Centre Retinal Stroke Study Group
Nov 21, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·François De GuioEric Jouvent
Sep 16, 2017·AJNR. American Journal of Neuroradiology·S DelormeE Jouvent
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Laurent PuyUNKNOWN GRECogVASC Study Group
Jul 26, 2018·Frontiers in Neurology·Edouard DuchesnayEric Jouvent
May 22, 2010·Current Opinion in Neurology·Jean-François ManginArnaud Cachia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.