PMID: 6540177Jun 1, 1984Paper

Measurement of cellular DNA content as an adjunct to diagnostic cytology in malignant effusions

European Journal of Cancer & Clinical Oncology
D W HedleyI W Taylor

Abstract

We reviewed the final diagnosis and outcome of 119 patients who developed serous effusions. In addition to routine cytological examination, the cellular DNA content of fluid samples aspirated from the effusions was measured using flow cytometry in order to determine whether the detection of aneuploid cells could aid in diagnosis or serve as a guide to prognosis. The final diagnosis of 35 patients was non-malignant and a further 40 patients with biopsy-proven cancer had cytologically negative effusions. In all of these cases flow cytometry revealed the presence of diploid cells only. The effusions from 36 cancer patients were reported by cytology to contain a variable proportion of malignant cells, and aneuploid cells were detected in 23 of these samples, the remainder containing only diploid cells. Of 8 effusions where cytology was equivocal, one contained aneuploid cells and clinical outcome subsequently showed that all 8 were malignant. Median survival of patients with cancer was 3 months, and a positive cytology had no influence on survival. However, of the patients with positive cytology, those whose effusions contained aneuploid cells had a poorer short-term prognosis than those cases where only diploid cells could be dete...Continue Reading

References

Sep 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W Taylor
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M L FriedlanderM H Tattersall
May 1, 1983·European Journal of Cancer & Clinical Oncology·I W TaylorD W Hedley
Jul 1, 1981·Cytometry·O D Laerum, T Farsund
Oct 1, 1980·Computers and Biomedical Research, an International Journal·B Milthorpe

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Citations

Feb 15, 1993·Cancer·P S Braly, R R Klevecz
Oct 3, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·R K GuptaS Naran
Nov 10, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Awtar KrishanMehrdad Nadji
Sep 1, 1984·European Journal of Cancer & Clinical Oncology·B Barlogie
May 26, 2001·The American Journal of Gastroenterology·C T BothM D Reis
Jul 20, 2006·Diagnostic Cytopathology·Awtar KrishanMehrdad Nadji
Jan 1, 1989·Journal of Clinical Laboratory Analysis·C A Hanson, B Schnitzer
Jan 1, 1992·The American Review of Respiratory Disease·M S KavuruH P Wiedemann
Jun 3, 1999·Diagnostic Cytopathology·H MotherbyA Böcking
Feb 6, 1998·Diagnostic Cytopathology·T J O'Leary
Jan 29, 2000·Diagnostic Cytopathology·I SahaR Nijhawan
Aug 1, 1995·Diagnostic Cytopathology·E S Cibas

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