Measurement of circulating troponin Ic enhances the prognostic value of C-reactive protein in haemodialysis patients

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Alexandre BoulierJean-Paul Cristol

Abstract

Cardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. They could be of predictive value in haemodialysis (HD) patients. However, the relationship between cTnI and the HD-induced inflammatory state remains unclear. The aim of this study was to explore the prognostic relevance to all-cause and cardiovascular mortalities in HD patients of cTnI, in combination with highly sensitive C-reactive protein (hs-CRP) levels. We measured cTnI and hs-CRP at baseline (March 10 to November 16, 2001) in 191 HD patients without clinical signs of acute coronary artery disease [median age 66.7 years (range 22.3-93.5), 94 females, 97 males]. We used a cTnI concentration with a total imprecision of 10% (0.03 microg/l), determined in the laboratory, as the analytical threshold value. Patients were followed for mortality until 1 January, 2003 (median follow-up 418 days). The adjusted relative risks (RRs) of death and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models. A significant proportion (25.1%) of patients had elevated CTnl, > or =0.03 microg/l; 40.3% of patients had CRP concentrations > or =10 mg/l. During follow-up, 29 patients died, 44.8% due to cardiac causes. E...Continue Reading

References

Aug 5, 1998·Kidney International·W F Owen, E G Lowrie
Mar 31, 2000·Seminars in Dialysis·P Chen, M Tanasijevic
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M P StoffelC A Baldamus
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S NakamuraG Kimura
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Diego BrancaccioVincenzo Panichi
Feb 14, 2002·Kidney International·Peter J Nelson, Thomas O Daniel
Jun 1, 2002·Annals of Clinical Biochemistry·Paul SheehanSamuel D Vasikaran
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca MallamaciLorenzo S Malatino
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheol Whee ParkByung Kee Bang
Mar 19, 2003·Seminars in Dialysis·Gérard M London
Apr 3, 2003·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Philippe ChauveauChristian Combe

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Citations

Dec 26, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Dejan Petrović, Biljana B Stojimirović
Aug 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Anne Marie DupuyJean Paul Cristol
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew A RobertsFrancesco L Ierino
Oct 21, 2005·International Journal of Clinical Practice·I BuhaescuA Covic
Oct 27, 2006·Social Science & Medicine·Thalia Bellali, Danai Papadatou
Jul 31, 2007·International Journal of Cardiology·Philippe BrunetYvon Berland
Dec 14, 2019·The American Journal of Emergency Medicine·Brit LongJonathan M Bronner

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