Abstract
Cardiac Troponin I (cTnI) levels are considered an important diagnostic tool in acute coronary events. They could be of predictive value in haemodialysis (HD) patients. However, the relationship between cTnI and the HD-induced inflammatory state remains unclear. The aim of this study was to explore the prognostic relevance to all-cause and cardiovascular mortalities in HD patients of cTnI, in combination with highly sensitive C-reactive protein (hs-CRP) levels. We measured cTnI and hs-CRP at baseline (March 10 to November 16, 2001) in 191 HD patients without clinical signs of acute coronary artery disease [median age 66.7 years (range 22.3-93.5), 94 females, 97 males]. We used a cTnI concentration with a total imprecision of 10% (0.03 microg/l), determined in the laboratory, as the analytical threshold value. Patients were followed for mortality until 1 January, 2003 (median follow-up 418 days). The adjusted relative risks (RRs) of death and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models. A significant proportion (25.1%) of patients had elevated CTnl, > or =0.03 microg/l; 40.3% of patients had CRP concentrations > or =10 mg/l. During follow-up, 29 patients died, 44.8% due to cardiac causes. E...Continue Reading
References
Aug 5, 1998·Kidney International·W F Owen, E G Lowrie
May 7, 1999·Kidney International·P StenvinkelT Jogestrand
Mar 31, 2000·Seminars in Dialysis·P Chen, M Tanasijevic
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M P StoffelC A Baldamus
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S NakamuraG Kimura
Sep 15, 2000·Journal of the American College of Cardiology·J S AlpertJ P Bassand
Oct 18, 2000·Circulation·J DierkesC Luley
Oct 5, 2001·Journal of the American College of Cardiology·I A KhanT J Sacchi
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Diego BrancaccioVincenzo Panichi
Feb 14, 2002·Kidney International·Peter J Nelson, Thomas O Daniel
Jun 1, 2002·Annals of Clinical Biochemistry·Paul SheehanSamuel D Vasikaran
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca MallamaciLorenzo S Malatino
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheol Whee ParkByung Kee Bang
Dec 4, 2002·Circulation·Fred S AppleCharles A Herzog
Dec 18, 2002·American Heart Journal·Fred S AppleAllan S Jaffe
Jan 25, 2003·Journal of Internal Medicine·C LöwbeerA Seeberger
Mar 19, 2003·Seminars in Dialysis·Gérard M London
Apr 3, 2003·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Philippe ChauveauChristian Combe
Citations
Dec 26, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Dejan Petrović, Biljana B Stojimirović
Oct 16, 2007·Cardiology·Phyo K MyintHelen M May
Aug 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Anne Marie DupuyJean Paul Cristol
Oct 22, 2014·Open Heart·David C Gaze, Paul O Collinson
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew A RobertsFrancesco L Ierino
Oct 21, 2005·International Journal of Clinical Practice·I BuhaescuA Covic
Nov 12, 2013·BMC Nephrology·Ahsan AlamAllan D Sniderman
Oct 27, 2006·Social Science & Medicine·Thalia Bellali, Danai Papadatou
Jul 31, 2007·International Journal of Cardiology·Philippe BrunetYvon Berland
Feb 27, 2018·Journal of the American Heart Association·Titi ChenAngela Makris
May 8, 2010·Renal Failure·Rüya MutluaySükrü Sindel
Dec 14, 2019·The American Journal of Emergency Medicine·Brit LongJonathan M Bronner