Measurement of collateral blood flow in a porcine model of aortic coarctation by velocity-encoded cine MRI

Journal of Magnetic Resonance Imaging : JMRI
D M ChernoffC A Gooding

Abstract

The purpose of this study was to investigate the time course of development of collateral blood flow in an animal model of aortic coarctation. A juxtaductal aortic stenosis (model coarctation) was surgically created in five juvenile pigs. MRI was performed preoperatively, 1 to 2 days postoperatively, and 2 to 10 weeks postoperatively. Aortic blood flow was measured by velocity-encoded cine MR (VENC-MR). The percent change in aortic blood flow (delta BF) from proximal to distal descending thoracic aorta was calculated, and a multiple-comparison paired t test used to assess changes in delta BF over time. Invasive flow measurements were obtained in one animal before sacrifice using an ultrasonic probe. delta BF preoperatively was -2 +/- 8% (mean +/- SE). delta BF increased to 32 +/- 7% (mean +/- SE, P = .022) 2 days postoperatively and 55 +/- 19% (P = .032) 2 to 8 weeks postoperatively. Invasive measurements were in qualitative agreement with the VENC-MR data. VENC-MR is an accurate noninvasive method of measuring collateral blood flow in aortic coarctation. Recruitment and development of collateral flow pathways occur rapidly in an animal model.

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Citations

May 15, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joachim LotzMichael Galanski
Mar 20, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jeffrey J HomGautham P Reddy
Feb 21, 2006·The Annals of Thoracic Surgery·Tiffany J RiehleW James Parks
Feb 2, 2010·International Journal of Cardiology·Sonya V Babu-NarayanMichael J Mullen

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Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.