PMID: 7536953Jan 1, 1995Paper

Measurement of colony-stimulating factors in synovial fluid: potential clinical value

Rheumatology International
A L BellA E Irvine

Abstract

In this study, 100 synovial fluid (SF) samples from patients with a variety of arthritides were assayed for levels of colony-stimulating factors (CSFs) using a human bone-marrow bioassay and enzyme immunoassays for granulocyte (G-) and granulocyte-macrophage (GM-) CSFs. GM-CSF was found more frequently in samples from rheumatoid arthritis (RA) subjects (49%) than in non-RA samples (29%). Absence of GM- but not G- or bioassay CSFs characterised samples from subjects with psoriatic arthritis and ankylosing spondylitis (n = 14). There was strong evidence of an antagonistic relationship between levels of G- and GM-CSFs in samples from RA patients, an effect independent of drug treatment. However, treatment with non-steroidal anti-inflammatory agents (NSAIDs) may affect reported CSF concentrations: G-CSF levels were significantly lower in samples from subjects not taking NSAIDs. These results suggest that SF-CSF estimations using commercially available assays could provide useful diagnostic clues for clinicians, but careful interpretation is warranted particularly in patients on long-term NSAID treatment.

References

Nov 1, 1992·British Journal of Rheumatology·I HoltS J Hopkins
Nov 1, 1992·British Journal of Rheumatology·A P Cope, F M Brennan
Nov 1, 1991·International Journal of Cell Cloning·K M Sakamoto, J C Gasson
Jan 1, 1990·Rheumatology International·J B SmithJ L Abruzzo

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Citations

Dec 14, 2012·Annals of the Rheumatic Diseases·Gerd R BurmesterUNKNOWN EARTH Study Group
Aug 30, 2008·Molecular Immunology·Stefan SteidlElisabeth Thomassen-Wolf
Feb 1, 2005·European Journal of Pharmacology·Paula ZacharowskiJane Mitchell
Feb 19, 2014·Human Vaccines & Immunotherapeutics·Gary ReynoldsCatharien M U Hilkens
Aug 13, 2013·Molecular Immunology·Annemarie van NieuwenhuijzeIan P Wicks
Jul 23, 2003·Memory & Cognition·Deanne L WestermanMarianne E Lloyd
Jun 19, 2019·Expert Opinion on Investigational Drugs·Chiara CrottiEnnio Giulio Favalli
Oct 20, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G D Godbold, B J Mann
Sep 25, 2017·Arthritis & Rheumatology·Michael E WeinblattGerd R Burmester
Feb 14, 2015·Zeitschrift für Rheumatologie·J R Kalden
Apr 30, 2017·Seminars in Immunopathology·Tommy Tsang Cheung, Iain B McInnes
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoyuki TanakaRobert L Modlin
Feb 19, 2017·Annals of the Rheumatic Diseases·Gerd R BurmesterUNKNOWN EARTH EXPLORER 1 study investigators
Feb 19, 2017·Seminars in Immunopathology·Mélissa Noack, Pierre Miossec
Aug 9, 2020·Frontiers in Immunology·Hui ShiPaul Bowness
Feb 12, 2021·Frontiers in Immunology·Cristina Municio, Gabriel Criado
Nov 14, 2020·Current Rheumatology Reviews·Laila Salah ShamseldinAnas Zakarya Nourelden

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