Measurement of coronary blood flow and flow reserve using magnetic resonance imaging

Cardiology
T M GristC M Mistretta

Abstract

It was the purpose of this study to demonstrate the feasibility of performing coronary artery flow and coronary flow reserve (CFR) measurements in normal human volunteers using a magnetic resonance (MR) phase contrast technique. Coronary flow rate, flow velocity, peak flow and CFR were determined at rest and during pharmacologically induced hyperemia in 10 healthy volunteers. The flow measurements were obtained during a single breath-hold by using a fast, prospectively gated, segmented k-space gradient-echo phase contrast acquisition with view sharing (FASTCARD PC) that was modified to improve sampling of the diastolic flow. Data were processed using the standard phase difference (PD) processing techniques as well as a new complex difference (CD) flow measurement method intended to improve the accuracy of flow measurements in small vessels. Mean hyperemic flow velocity (40 +/- 16 cm/s) and blood flow (3.9 +/- 1.5 ml/s) rates differed significantly from resting velocity (13 +/- 6.6 cm/s) and flow (1.1 +/- 0.4 ml/s) measurements (p < 0.0001). PD methods consistently measured larger flow rates at rest (24% larger, p < 0.0005) and stress (29% larger, p < 0.0001). CFR, calculated as the ratio of the mean PD flows (4.7 +/- 2.8), was ...Continue Reading

Citations

Nov 5, 1999·Journal of Magnetic Resonance Imaging : JMRI·H SakumaC B Higgins
Apr 16, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E NagelE Fleck
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C M TsaiD G Nishimura
Feb 17, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H SakumaK Takeda
Jul 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·Michael MarklJürgen Hennig
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K L WeddingC A Mistretta
May 1, 2001·Journal of Magnetic Resonance Imaging : JMRI·H ArhedenF Ståhlberg
Mar 13, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·John CarnageyChristine E Schmidt
Dec 6, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hung-Yu LinOrlando P Simonetti
Jul 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D J Hildick-Smith, L M Shapiro
Jun 10, 1998·Magnetic Resonance Imaging Clinics of North America·S O SchoenbergJ R Allenberg
May 4, 2020·International Journal for Numerical Methods in Biomedical Engineering·Navid FreidoonimehrAnthony Zander
Feb 11, 2005·Acta Paediatrica. Supplement·H Sakuma, C B Higgins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.