PMID: 22554278May 5, 2012Paper

Measurement of CYP1A2 activity: a focus on caffeine as a probe

Current Drug Metabolism
Vidya PereraAndrew J McLachlan

Abstract

The drug metabolising enzyme CYP1A2 contributes to the metabolism of a number of medicines including clozapine, olanzapine and theophylline. These medicines display a high degree of inter-individual variability in pharmacokinetics and response. Measuring CYP1A2 activity in vivo can be an important tool to identify the factors that influence variability in drug pharmacokinetics and inform dose selection. Caffeine is the only currently accepted probe to conduct in vivo phenotyping of CYP1A2. Despite the number of proposed matrices (biological fluid containing the drug and/or metabolite/s of interest) and metrics (mathematical formula relating the drug and/or metabolite/s to enzyme activity) proposed to measure CYP1A2 activity using caffeine, many of these are compromised by factors related to the specific metabolic pathway studied or pharmacokinetic characteristics of caffeine and its metabolites. Furthermore, questions regarding the appropriate study design and methodology to conduct studies to evaluate CYP1A2 activity have often been overlooked. These issues include the potential influence of a methylxanthine abstinence period prior to caffeine CYP1A2 phenotyping and the impact of caffeine formulation on determining CYP1A2 acti...Continue Reading

Citations

Jul 2, 2014·Clinical Pharmacokinetics·Pieter M M De KeselChristophe P Stove
Dec 4, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Natacha LenuzzaHenri Bénech
Aug 7, 2014·Bioanalysis·Pieter Mm De KeselChristophe P Stove
Mar 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Sun Joo KimSangkyu Lee
Jan 12, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sun Joo KimSangkyu Lee
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Vidya PereraAndrew J McLachlan
May 7, 2013·Expert Opinion on Drug Metabolism & Toxicology·Vidya PereraAndrew J McLachlan
Jun 4, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Nan Yeun JordanJavier Sastre Torano
Jun 10, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Sun Ju KimSangkyu Lee
Oct 4, 2014·Schizophrenia Research·J-M BatailD Drapier
Jun 28, 2017·The Journal of Pharmacy and Pharmacology·Qingxiang ZhongXiaobin Jia
Dec 29, 2017·The Pharmacogenomics Journal·Nut KoonrungsesomboonSupanimit Teekachunhatean
Aug 17, 2018·Acta Psychiatrica Scandinavica·M Na TakuathungN Koonrungsesomboon
Sep 3, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vidya PereraAndrew J McLachlan
Jul 7, 2018·Arthritis Research & Therapy·Joseph HuttonNicola Dalbeth
Jan 3, 2021·Biopharmaceutics & Drug Disposition·Younah KimSangkyu Lee
May 12, 2021·Scientific Reports·Giorgio LeodoriAlfredo Berardelli
Mar 12, 2015·Journal of Agricultural and Food Chemistry·Elisabetta SchievanoLuciano Navarini
Oct 7, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Shahin MinaeiDouglas Kalman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Drug Metabolism and Drug Interactions
J Jenner, G H Dodd
Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
R J Maughan, J Griffin
© 2021 Meta ULC. All rights reserved