Abstract
Contact allergen-induced migration of epidermal Langerhans cells (LCs) to draining lymph nodes is dependent upon receipt by LCs of at least two cytokine signals provided by tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta. It has been reported previously that intradermal injection of healthy human volunteers with homologous TNF-alpha or IL-1beta each induces a significant reduction in LC frequency, as measured in epidermal sheets prepared from 6-mm punch biopsies. In the current experiments, we have compared the frequency of LCs in punch biopsies with those obtained concurrently in epidermal sheets from the roofs of suction blisters isolated from the sun-protected buttock skin of healthy adult volunteers. There was a significant, approximately 30%, reduction in CD1a(+) LC numbers in suction blister roofs compared with punch biopsies. Injection of homologous recombinant IL-1beta, a stimulus that provokes measurable epidermal LC mobilization in punch biopsy sites, failed to provoke further LC migration in suction blister sites. These data suggest that the mechanical trauma to the skin caused by the creation of suction blisters provokes the degree of cutaneous inflammation necessary for LC mobilization. The respo...Continue Reading
References
Sep 1, 1992·The British Journal of Dermatology·T HunzikerL R Braathen
Jan 1, 1992·Archives of Dermatological Research·C U BrandL R Braathen
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Oct 1, 1990·Immunological Reviews·J W StreileinM Vermeer
Dec 1, 1987·The Journal of Experimental Medicine·S E MacatoniaP Fryer
Apr 1, 1988·The British Journal of Dermatology·J AshworthS M Breathnach
Jan 1, 1995·The Journal of Investigative Dermatology·A ShibakiK D Cooper
Sep 1, 1995·Immunology Today·J Brock
Oct 1, 1995·The Journal of Investigative Dermatology·L E RhodesP S Friedmann
Apr 1, 1996·The Journal of Experimental Medicine·L P ShornickD D Chaplin
Mar 5, 1998·Immunology·M CumberbatchI Kimber
Jan 23, 1999·Current Opinion in Immunology·I KimberR J Huby
May 8, 1999·The Journal of Investigative Dermatology·R M BarrA R Young
Jul 31, 1999·Immunopharmacology·M CumberbatchI Kimber
Aug 3, 1999·Acta Dermato-venereologica·L E RhodesP S Friedmann
Sep 1, 1999·The British Journal of Dermatology·M CumberbatchI Kimber
Mar 29, 2000·The British Journal of Dermatology·I KimberC E Griffiths
Apr 12, 2001·The British Journal of Dermatology·C E GriffithsI Kimber
Apr 12, 2001·Immunology·M CumberbatchI Kimber
Oct 26, 2001·The Journal of Investigative Dermatology·L E RhodesP S Friedmann
Feb 14, 2002·The British Journal of Dermatology·M BhushanC E M Griffiths
Mar 6, 2002·Archives of Dermatological Research·Silvia SebastianiGiampiero Girolomoni
May 2, 2002·The Journal of Investigative Dermatology·Wendy KölgenFrank R De Gruijl
Jul 26, 2002·Toxicology and Applied Pharmacology·Marie CumberbatchIan Kimber
Apr 18, 2003·Clinical and Experimental Immunology·M CumberbatchC E M Griffiths
Citations
Jun 22, 2006·Contact Dermatitis·Cindy M De JonghSanja Kezic
Sep 3, 2010·PloS One·Marc PeartonJames C Birchall
Jan 8, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xin ZhaoStephanie J Hanna
Feb 9, 2007·Experimental Dermatology·Andrea TuettenbergHelmut Jonuleit
Feb 5, 2008·Alcoholism, Clinical and Experimental Research·Kristin J NessAnnette J Schlueter
May 10, 2006·Clinical and Experimental Dermatology·N MacdonaldI Kimber
May 13, 2006·Experimental Dermatology·Cynthia L LehéPranab K Das
May 13, 2006·Experimental Dermatology·John J L JacobsPranab K Das
Oct 3, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Cindy M de JonghSanja Kezic
Dec 30, 2014·Parasite Immunology·R N CottonR Tolouei Semnani
Jul 30, 2014·The British Journal of Dermatology·L K HatjeJ Kottner
Aug 22, 2015·Immunology·Mohammad Alhadj AliDanijela Tatovic
Feb 22, 2011·Brain, Behavior, and Immunity·Jing HuangRichard D Granstein
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf
Nov 26, 2009·Electrophoresis·Terry M PhillipsEdward Wellner
Sep 14, 2014·EMBO Molecular Medicine·Elisabeth GlitznerMaria Sibilia
Jul 20, 2012·Physiological Reviews·Helge Wiig, Melody A Swartz
Aug 18, 2012·Experimental Dermatology·Katayun AdhamiRichard D Granstein
Jun 11, 2015·Physiological Reports·Mads Radmer JensenJens Bülow
Oct 19, 2017·Experimental and Therapeutic Medicine·Yinan DaiXinze Cai
Jan 25, 2021·European Journal of Cell Biology·Magnus S ÅgrenLise Mette Rahbek Gjerdrum