PMID: 8972883Sep 1, 1996Paper

Measurement of DNA adducts in humans after complex mixture exposure

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C M Dale, R C Garner

Abstract

In contrast to acute or chronic dosing experiments with a single chemical in animals, man is exposed to thousands of chemicals during a lifetime. Each of these may act alone, additively, synergistically or antagonistically in terms of biological effects, but most current risk assessment procedures fail to recognize such interactions. In carcinogenesis, a mutational process that is thought to occur through DNA damage by endogenous and/or exogenous agents, a wide variety of host factors is involved in disease outcome. These include absorption of chemicals, their distribution, metabolism and excretion. In addition, once metabolic activation has occurred, there is an array of protective mechanisms that cells have evolved to maintain DNA integrity, such as DNA repair, genetic redundancy and programmed cell death. One approach to risk assessment is to regard all DNA-damaging events as potentially leading to cancer and to measure DNA damage as the biologically relevant endpoint. The main method, if not the only method, presently available to assay a wide range of DNA adducts is 32P-postlabelling. This method has high sensitivity (limit of detection > 1 adduct per 10(10) nucleotides) and is capable of visualizing many different DNA add...Continue Reading

References

Jul 1, 1992·Mutation Research·M N RoutledgeJ Cuzick
Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·G W DykeR C Garner
Mar 1, 1992·The Clinical Investigator·G SchererF Adlkofer
Jul 1, 1992·Carcinogenesis·A C Beach, R C Gupta
Oct 1, 1991·Journal of Toxicology and Environmental Health·M V ReddyK Randerath
Sep 1, 1991·Mutation Research·B N Ames, L S Gold
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·B P DunnH F Stich
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G TalaskaF F Kadlubar
Apr 1, 1990·Carcinogenesis·P L Skipper, S R Tannenbaum
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·D H PhillipsI Vincze
Jan 1, 1990·International Archives of Occupational and Environmental Health·K HemminkiA Hewer
Apr 15, 1990·International Journal of Cancer. Journal International Du Cancer·J CuzickR C Garner
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K W TurteltaubJ C Davis
Mar 1, 1989·Journal of the National Cancer Institute·E RanderathK Randerath
Aug 1, 1987·Rapid Communications in Mass Spectrometry : RCM·J J DinoD G Kaufman
Aug 1, 1988·Carcinogenesis·S F LiuW J Bodell

❮ Previous
Next ❯

Citations

Jul 24, 1998·Mutation Research·R C Garner
Jul 16, 1999·Analytical Biochemistry·C B Norwood
Mar 1, 2009·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Jennifer E Lansford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.