Measurement of enterolactone and enterodiol, the first mammalian lignans, using stable isotope dilution and gas chromatography mass spectrometry

Biomedical Mass Spectrometry
K D SetchellM Axelson

Abstract

Methods are described to extract and measure 2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone (enterolactone) and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol (enterodiol) from physiological fluids. They are based on the use of stable labelled analogues of each compound as internal standards with end point assay being by gas chromatography mass spectrometry. The methods were developed to quantify enterolactone and enterodiol in experiments designed to investigate the significance and source of these compounds in man and animals. Examples of studies on human ovarian blood and investigations of their excretion in urine following dietary manipulation are described.

References

Sep 14, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·K D Setchell, C H Shackleton
Oct 23, 1980·Nature·K D SetchellM Axelson
Nov 6, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·C H Shackleton, J O Whitney
Dec 15, 1980·FEBS Letters·M Axelson, K D Setchell
Jun 3, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·T FotsisK D Setchell
Sep 1, 1982·Journal of Reproduction and Fertility·L DehenninM Thibier
Jun 1, 1963·Analytical Biochemistry·M MAKITA, W W WELLS

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Citations

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzT Hase
Feb 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzL E Vickery
Mar 1, 1996·The Proceedings of the Nutrition Society·A Cassidy
Jan 1, 1991·Nutrition and Cancer·L U ThompsonF Cheung
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Li-Quan Wang
Jun 18, 2003·Rapid Communications in Mass Spectrometry : RCM·Philip B GraceSheila A Bingham
Jun 20, 2007·Molecular Nutrition & Food Research·Niina M SaarinenSari Mäkelä
Apr 1, 1986·Biomedical Chromatography : BMC·G BrunnerK D Setchell
Jan 1, 1985·The Journal of Applied Bacteriology·S P BorrielloA M Lawson
Feb 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·U KnustR W Owen
Apr 4, 2003·Analytical Biochemistry·Philip B GraceSheila A Bingham
Mar 31, 2015·Journal of Agricultural and Food Chemistry·Monika Pohjoispää, Kristiina Wähälä
Apr 15, 1992·Cancer Letters·M Serraino, L U Thompson
Oct 14, 2017·Critical Reviews in Food Science and Nutrition·Muhammad H Alu'dattInteaz Alli
Sep 6, 2012·Journal of Zhejiang University. Science. B·Kai JiangHang Chen
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H AdlercreutzT Hase
Mar 1, 2005·The Journal of Nutrition·Hongyan QuWeiqun Wang
Dec 7, 2002·The Journal of Nutrition·Kenneth D R SetchellEva Lydeking-Olsen
Mar 17, 1989·Journal of Chromatography·J UusijärviJ Sjövall

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