PMID: 8611407Apr 1, 1996Paper

Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis

British Journal of Cancer
B Blöchl-DaumH Pehamberger

Abstract

Clinical anti-tumour efficacy of anti-cancer drugs is a function of dose intensity, i.e. the concentration--time profile in tumour tissue. Hence, information on drug concentration profiles in tumours is of critical importance but appropriate methods for measurement are lacking. The aim of the present study was to obtain, by microdialysis sampling, concentration--time profiles in a solid tumour (melanoma) of a model anti-cancer drug, carboplatin, and thereby to assess the scope of microdialysis for tumour pharmacokinetic studies in man. Six patients with cutaneous melanoma metastases at the extremities or body trunk, scheduled to receive carboplatin (400 mg m-2 i.v.) were studied. Carboplatin concentrations were monitored in serum, intratumoral and subcutaneous tissue. Calibration of the microdialysis probes was carried out in vitro and in vivo with use of the retrodialysis method. Complete carboplatin concentration vs time profiles in tumour and subcutaneous tissue were obtained. Major pharmacokinetic parameters (maximum concentration, time to maximum concentration, area under the curve, elimination half-life) were calculated for tissues and tumour/serum concentration ratios for carboplatin were derived. Mean free concentration...Continue Reading

Citations

Apr 14, 2016·Pharmaceutical Research·Maiara Cássia PigattoTeresa Dalla Costa
Dec 14, 2018·International Journal of Molecular Sciences·Blendi UraGiuseppe Ricci
Aug 27, 2005·Clinical Pharmacokinetics·Christian Joukhadar, Markus Müller
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Aug 1, 1997·Clinical Pharmacology and Therapeutics·M MüllerH G Eichler
Jul 24, 2010·Cancer Chemotherapy and Pharmacology·Inge R H M KoningsWalter J Loos
Nov 22, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·E RichtigJ Smolle
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