PMID: 9541124Apr 16, 1998Paper

Measurement of free fatty acid kinetics during non-equilibrium tracer conditions in man: implications for the estimation of the rate of appearance of free fatty acids

European Journal of Clinical Investigation
S C RiemensW J Sluiter

Abstract

This study aimed to document the applicability and variability of free fatty acid (FFA) kinetic parameters during non-equilibrium and equilibrium tracer conditions in man. FFA kinetic parameters were assessed after an overnight fast in six healthy non-obese and three obese subjects as well as in three patients with non-insulin-dependent diabetes mellitus (NIDDM) by infusion of [14C]-palmitate of 60 min (study A) and 10 min duration (study B). The kinetic parameters estimated from the upstroke and downstroke of the plasma FFA specific activity curve (non-equilibrium) were not statistically different within studies A and B. Furthermore, there were no significant differences in any of the FFA kinetic parameters between studies A and B. The averaged plasma levels of FFA obtained during the up- and downstroke from studies A and B were higher in obese subjects and NIDDM patients than in non-obese subjects (P < 0.01). The averaged total rate of appearance (TRa) of FFA was higher in obese subjects than in non-obese subjects (P < 0.02). The TRa and metabolic clearance rate (MCR), estimated from non-equilibrium conditions, were about 25% higher than the apparent values obtained from steady-state measurement in all subjects combined (P < ...Continue Reading

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Citations

Jan 18, 2003·The Journal of Clinical Investigation·Katrin HückingRichard N Bergman
May 28, 2013·Biochimica Et Biophysica Acta·Stephen F PrevisThomas P Roddy

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