Measurement of free radical production by in vivo microdialysis during ischemia/reperfusion injury to skeletal muscle

Free Radical Biology & Medicine
David M PattwellM J Jackson

Abstract

Microdialysis techniques have been used to detect hydroxyl radical and superoxide release into the interstitial space of anaesthetized rat anterior tibialis muscles during a period of prolonged (4 h) limb ischemia and subsequent reperfusion. Data indicate that reperfusion of the ischemic skeletal muscle was associated with a large increase in hydroxyl radical activity in the interstitial space, which may contribute to the significant oxidation of muscle glutathione, protein thiols, and lipids also seen in this model. No evidence for release of superoxide into the interstitial space was found during reperfusion, although this was observed during electrically stimulated contractile activity of the rat limb muscle. These data imply that therapeutic approaches aimed at reduction of hydroxyl radical generation in the interstitial fluid are more likely to be beneficial in reduction of skeletal muscle reperfusion injury than approaches designed to scavenge superoxide radicals.

References

Feb 1, 1991·European Journal of Vascular Surgery·S OredssonP Qvarfordt
Jan 1, 1990·Progress in Neurobiology·H Benveniste, P C Hüttemeier
Dec 1, 1984·Archives of Biochemistry and Biophysics·D Di MonteS Orrenius
Nov 1, 1994·International Journal of Microcirculation, Clinical and Experimental·R F PotterA C Groom
Aug 1, 1995·Acta Orthopaedica Scandinavica·L KlenermanM J Jackson
May 17, 1996·Biochemical Pharmacology·T Obata, Y Yamanaka
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·T Obata
Feb 14, 1998·The Journal of Clinical Investigation·M ArrasW Schaper
Sep 10, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D J BowlerD Bouchier-Hayes
Jan 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander V CroweMalcolm J Jackson

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Citations

May 23, 2002·BioFactors·M J JacksonA McArdle
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Malcolm J Jackson
Jun 28, 2011·Journal of Applied Physiology·Li ZuoMichael C Hogan
Jul 29, 2009·American Journal of Respiratory Cell and Molecular Biology·J Richard SkellyKen D O'Halloran
Oct 15, 2013·Canadian Journal of Physiology and Pharmacology·Rosario SolisJorge A Sánchez
Jan 15, 2008·Free Radical Biology & Medicine·Michael B Reid
May 15, 2007·Immunological Reviews·Emily J Swindle, Dean D Metcalfe
Feb 8, 2005·Medical Hypotheses·Boguslaw Lipinski
Sep 30, 2004·Free Radical Biology & Medicine·Joel EscobedoTimothy J Koh
Sep 1, 2004·Free Radical Biology & Medicine·David M PattwellMalcolm J Jackson
Sep 10, 2005·Journal of Pineal Research·Korhan ErkanliKaan Kirali
Jun 27, 2008·Medicine and Science in Sports and Exercise·Andrew C BulmerIan B Stewart
Jul 18, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhihong TongHaidong Liang
Mar 25, 2005·American Journal of Physiology. Cell Physiology·Li Zuo, Thomas L Clanton
Mar 21, 2012·Journal of Orthopaedic Trauma·Daniel StahlRussell Ward
Nov 4, 2009·The Journal of Bone and Joint Surgery. American Volume·Russell WardEd Childs
Jun 23, 2020·The Journal of Pharmacy and Pharmacology·Jinwu WangLeyi Cai
Aug 29, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mehmet KirisciUlku Kazanci
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li ZuoMichael C Hogan
Dec 31, 2002·Journal of Applied Physiology·Li ZhangJames R Urbaniak
May 7, 2005·Free Radical Research·Dylan ThompsonRex M Tyrrell
Jan 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·David PattwellMalcolm J Jackson
Feb 26, 2014·Physiological Research·J D La FavorR C Hickner
Feb 17, 2006·Respiratory Physiology & Neurobiology·Melissa A Smith, Michael B Reid

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