Feb 1, 1976

Measurement of gastric functions during digestion of ordinary solid meals in man

Gastroenterology
J R MalageladaV L Go

Abstract

A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quantifies emptying into the duodenum of another marker, [14C]PEG, incorporated in the meal. Acid and pepsin outputs can be determined without manipulation of the intragastric pH. Employing this method, we have simultaneously quantified acid, pepsin, and total secretory outputs; rates of gastric emptying of meal and secretions; and serum gastrin levels during digestion. These data characterize physiological responses to ordinary food in health.

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Mentioned in this Paper

Gastric Juice
Duodenum
Pepsin 3
Gastric Emptying
Malignant Neoplasm of Pylorus
Polyethylene Glycols
Gastric Acidity Determination
Malignant Neoplasm of Duodenum
Ingestion
Vigilon

About this Paper

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