Measurement of gastrointestinal intramucosal pH is a poor guide to tolerable levels of anemia during isovolemic hemodilution in a canine model of coronary stenosis

Archives of Surgery
M LaylandB J Leone

Abstract

To determine the relationship between gastrointestinal intramucosal pH and myocardial oxygenation during isovolemic hemodilution in dogs with critical coronary artery stenoses. Prospective sequential evaluation of ileal intramucosal pH and regional myocardial function of a critically perfused area of myocardial tissue in a canine model of normovolemic hemodilution. A research laboratory. Fifteen dogs. A micrometer snare was placed around a main coronary artery (8 left anterior descending artery, 7 right coronary artery). Three pairs of sonomicrometer crystals were placed in the heart to measure regional myocardial contraction. A gastrointestinal tonometer was placed in the ileum and used to measure luminal PCO2. This PCO2 value was used to calculate the ileal intramucosal pH. The animals underwent normovolemic hemodilution until myocardial ischemia occurred in the region supplied by the snared vessel. Measurements were continued for a further 40 minutes. Following instrumentation, stabilization, and critical constriction of a coronary vessel, percentage changes in systolic shortening of myocardial tissue in the region of critical perfusion were determined every 20 minutes. Ileal intramucosal pH and commonly measured cardiovascu...Continue Reading

Citations

Nov 22, 2000·The Journal of Trauma·L N DiebelS A Dulchavsky
Dec 24, 2004·Anesthesia and Analgesia·Michael G Mythen
Oct 3, 2006·Current Opinion in Anaesthesiology·D R Spahn, T Pasch
Dec 31, 2004·The Journal of Trauma·Arnaldo DubinGraciela Etcheverry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.