PMID: 2115049May 1, 1990Paper

Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 51Cr-EDTA clearance, creatinine clearance, serum creatinine and beta 2 microglobulin

Journal of Clinical Pathology
S A AparicioGraham R Serjeant

Abstract

Glomerular filtration rates (GFR) were measured with 51Cr-EDTA in 38 patients (aged 40-75 years) with homozygous sickle cell disease and compared with serum beta 2 microglobulin concentrations in 38 patients and with creatinine clearance in 21 patients. GFR estimated with 51Cr-EDTA was closely correlated with single serum creatinine measurements and the inverse of serum beta 2 microglobulin. Creatinine clearance was also found to be correlated, but values were, on average, 32% below those obtained by the 51Cr-EDTA method, and this difference was significant. It is concluded that measurements of beta 2 microglobulin, single serum creatinine, and creatinine clearance are valuable indicators of GFR in homozygous sickle cell disease. Measurement of beta 2 microglobulin was a useful and reliable method of estimating GFR from single plasma measurements and is therefore a useful means of screening the population.

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Citations

Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amy M Becker
May 10, 2003·Journal of Diabetes and Its Complications·Olusegun A Mojiminiyi, Nabila Abdella
Mar 29, 2006·Journal of Clinical Pathology·R MaroufH Al Wazzan
Aug 30, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiGian Cesare Guidi
Aug 13, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Erin Hall HolderScott A Brown
Oct 11, 2014·Blood Cells, Molecules & Diseases·Monika Asnani, Marvin Reid
Jun 23, 2015·Nigerian Journal of Clinical Practice·A J MaduA Eze
Mar 1, 1994·Artificial Organs·R BambauerJ Vienken
Jul 1, 2017·Frontiers in Medicine·Christos P ArgyropoulosAntonios H Tzamaloukas

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