Measurement of glomerular filtration rate in children with insulin-dependent diabetes mellitus

Clinica Chimica Acta; International Journal of Clinical Chemistry
D M GibbM T Barratt

Abstract

51Cr-EDTA, inulin and creatinine clearances were measured simultaneously in 11 diabetic children and 12 healthy young adults. The clearances in all individuals were 115 +/- 24 ml/min per 1.73 m2SA for 51Cr-EDTA, 118 +/- 25 ml/min per 1.73 m2SA for inulin and 157 +/- 35 ml/min per 1.73 m2SA for creatinine. Values were higher in the diabetic children but the differences were not significant. 51Cr-EDTA clearance significantly underestimated that of inulin by a mean of -7.4 +/- 2.5 (SEM) ml/min per 1.73 m2SA (p less than 0.01) and creatinine clearance significantly overestimated that of inulin by 37.6 +/- 3.3 (SEM) ml/min per 1.73 m2SA (p less than 0.0001). Similarly, the mean ratio of 51Cr-EDTA to inulin clearance was 0.94 (95% CI 0.90-0.98) and that of creatinine to inulin clearance was 1.32 (95% CI 1.27-1.37); the differences between diabetics and controls were not significant. Correlation coefficients were 0.93 between 51Cr-EDTA and inulin clearances, and 0.95 between inulin and creatinine clearances. The pooled coefficient of variation between clearances within an individual was higher with inulin, 10.3 +/- 6.5% (SD), than 51Cr-EDTA, 7.3 +/- 5.1% (p less than 0.001, t test). These results show that 51Cr-EDTA clearance underest...Continue Reading

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Citations

Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F ChiarelliG Morgese
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·George J Schwartz, Susan L Furth
Oct 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M KrügerR Burghard
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey J FadrowskiSusan L Furth
May 21, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Inga SoveriUNKNOWN SBU GFR Review Group
Dec 31, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cherry MammenDouglas G Matsell
Apr 27, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hans Pottel
Feb 20, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tatjana Van Der HeggenPieter A De Cock
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George J Schwartz, Dana F Work
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey J Fadrowski, Susan L Furth

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