PMID: 8616024Mar 1, 1996Paper

Measurement of health-related quality of life in multiple myeloma. Nordic Myeloma Study Group

British Journal of Haematology
F WisløffJ Westin

Abstract

When a randomized trial (NMSG 4/90) comparing treatment with melphalan/prednisone to melphalan/ prednisone + interferon alpha-2b in newly diagnosed multiple myeloma was initiated in 1990, a quality-of-life assessment was integrated into the study. We used the questionnaire (QLQ-C30) developed by the European Organization of Research and Treatment of Cancer (EORTC) Study Group on Quality of Life. The QLQ-C30 incorporates five functional scales, three symptom scales, a global health and quality-of life scale and some single symptom measures. The questionnaire was completed prior to treatment and after 1, 6, 12, 24, 36 and 48 months. 524 (90.2%) of 581 patients enrolled in the NMSG 4/90 completed the first questionnaire, and 484 (83.3%) completed all questionnaires given to them. All but one of the scales met the minimum criteria of reliability (Cronbach's alpha >/ 0.70). Validity was shown by (1) the ability of the scales to discriminate clearly between patients differing in clinical status as defined by pretreatment W.H.O. performance index and Durie & Salmon stage, and (2) the sensitivity to changes in objective disease status (response and relapse). This is the first report of the measurement of health-related quality of life ...Continue Reading

Citations

May 19, 1998·Leukemia Research·A G Smith, S E Crofts
Aug 18, 2000·Journal of Pain and Symptom Management·P KlepstadS Kaasa
Jul 19, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L Hakamies-BlomqvistC Blomqvist
Oct 16, 1999·British Journal of Haematology·I TuressonF Wislöff
Feb 7, 2013·Journal of Hematology & Oncology·Desiree JonesTito R Mendoza
Apr 5, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Marjan J WestermanAnne-Mei The
Dec 5, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·A J M BeijersF Mols
Jul 8, 2005·European Journal of Haematology·Jeanette DoorduijnPieter Sonneveld
Jan 19, 2005·European Journal of Haematology·C A Uyl-de GrootP C Huijgens
Apr 3, 2004·British Journal of Haematology·Anders WaageUNKNOWN Nordic Myeloma Study Group
Nov 20, 2016·Expert Review of Hematology·Federico De MarchiMario Tiribelli
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique DuboisChristine de la Loge
Mar 23, 2017·European Journal of Haematology·Lene Kongsgaard NielsenNiels Abildgaard
Nov 6, 2003·Clinical Orthopaedics and Related Research·Edward Y Cheng
May 4, 2016·The American Journal of Hospice & Palliative Care·Fiona KielyTony O'Brien
Oct 26, 2005·Bone Marrow Transplantation·C I ChenA K Stewart
Mar 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C G SchaarUNKNOWN Dutch-Belgian Hemato-Oncology Cooperative Group HOVON
Mar 17, 2009·European Journal of Haematology·Anna T JohnsenMogens Groenvold
Jan 19, 2019·British Journal of Haematology·Lene Kongsgaard NielsenTobias Wirenfeld Klausen
Jun 30, 2019·Expert Review of Hematology·Massimo MartinoMassimo Gentile
Sep 25, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Lene Kongsgaard NielsenNiels Abildgaard

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