Measurement of homonuclear proton couplings from regular 2D COSY spectra

Journal of Magnetic Resonance
F DelaglioA Bax

Abstract

An interactive computer procedure is described which determines (1)H--(1)H couplings from fitting the cross-peak multiplets in regular phase-sensitive COSY spectra. The robustness and simplicity of the method rely on the fact that a given cross-peak intensity is not an independent variable in the fitting procedure, making it possible to measure couplings accurately even from individual cross peaks with unresolved multiplet structure.

Citations

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