Measurement of human chorionic gonadotropin-related immunoreactivity in serum, ascites and tumour cysts of patients with gynaecologic malignancies

European Journal of Clinical Investigation
M GrossmannK Mann

Abstract

Human chorionic gonadotropin (hCG)-like molecules have been reported to be elevated in a substantial fraction of serum samples from patients with various gynaecologic tumours and have been discussed as possible markers in these malignancies. Employing highly sensitive and specific immunoradiometric assays, we determined total hCG-related immunoreactivity (hCG/hCG beta), as well as free alpha-subunit (alpha-SU), common to all glycoprotein hormones, in serum (n = 106) and malignant effusions (n = 26) of women with gynaecologic malignancies. For comparison, we also measured hCG/hCG beta in nonmalignant ascitic fluids (n = 21). HCG/hCG beta serum levels were elevated (> 5 IU L-1) in 39 of 106 patients (37%) with gynaecologic malignancies, whereas free alpha-SU was above normal range only in seven (6.6%). Frequencies of hCG/hCG beta elevations were similar in women with endometrial, (n = 39), cervical (n = 40) and ovarian (n = 27) cancer, being 30%, 35% and 41%, respectively. In malignant ascites (n = 15) and tumour cyst fluids (n = 11) of patients with ovarian cancer, hCG/hCG beta concentrations were significantly higher than in the corresponding serum samples and benign ascitic samples. Free alpha-SU, on the other hand, was increa...Continue Reading

References

Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·E M Rutanen
Jan 1, 1992·Gynecologic and Obstetric Investigation·S A Farghaly
Jun 17, 1992·JAMA : the Journal of the American Medical Association·P M MarzukC S Hirsch
May 1, 1990·The Journal of Endocrinology·P BergerG Wick
Jan 1, 1990·Seminars in Surgical Oncology·G J OltR C Bast
Nov 1, 1989·Human Reproduction·R G Edwards
Mar 1, 1980·Cancer·E S DonaldsonJ van deVoorde
May 15, 1984·American Journal of Obstetrics and Gynecology·S CasperE J Pavlik
Jan 1, 1981·Annual Review of Biochemistry·J G Pierce, T F Parsons
Feb 15, 1982·Cancer·A BlausteinJ Wells

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Citations

Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A JankowskaJ B Warchol
May 16, 2009·Biosensors & Bioelectronics·Karen D DanielMichael J Cima
Mar 11, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joseph C WildenbergLisa P Jones
Jul 6, 2004·Clinical Biochemistry·Ulf-Håkan StenmanKristina Hotakainen
Oct 3, 2017·The International Journal of Biological Markers·Alexandra C KölblUlrich Andergassen
Jun 2, 2001·Hospital Medicine·J Jeffery, M J Murphy
Feb 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anna G JankowskaProf Jerzy B Warchol
Aug 1, 2006·Human Reproduction Update·Ulf-Håkan StenmanLeena Valmu
Jun 6, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kojo R RawishOluwole Fadare
Jul 29, 1998·Annals of Clinical Biochemistry·C M Sturgeon, E J McAllister
Sep 26, 2007·Bioconjugate Chemistry·Grace Y KimMichael J Cima
Jul 27, 2010·Molecular and Cellular Endocrinology·R K IlesS A Butler

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