Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: influence of the route of administration on the activity against resistant Haemonchus contortus in lambs

Experimental Parasitology
M LloberasA Lifschitz

Abstract

The influence of the administration route on the relationship between efficacy and ivermectin concentration profiles achieved in the bloodstream, the gastrointestinal mucosal tissues/fluid contents and within a target abomasal parasite (Haemonchus contortus) was evaluated in lambs. Twenty-six (26) parasitized lambs were assigned into three experimental groups: untreated (control) and ivermectin treated by the subcutaneous and intraruminal route at 0.2mg/kg. Blood samples were collected between 0 and 15 days post-treatment (plasma disposition study). Four animals from each group were sacrificed at day 3 post-treatment. Mucosa and content samples from abomasum and small intestine and adult specimens of H. contortus were collected. Drug concentrations were measured by HPLC. Individual fecal egg counts were evaluated at -1, 3 and 15 days post treatment. Post-mortem examination was done at day 15 post-treatment. Adult nematodes recovered from the digestive tract were counted and identified by species. Ivermectin plasma availability was higher (P<0.05) after the subcutaneous administration (129 ng.d/ml) compared to the intraruminal treatment (58.4 ng.d/ml). However, ivermectin concentrations measured in the gastrointestinal contents ...Continue Reading

References

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Citations

Apr 20, 2014·PloS One·Guillermina Hernando, Cecilia Bouzat
Jul 8, 2014·European Journal of Pharmacology·Mélanie AlbérichAnne Lespine
Dec 10, 2013·Veterinary Parasitology·Carlos LanusseAdrian Lifschitz
Sep 21, 2013·Expert Opinion on Drug Metabolism & Toxicology·Anne Lespine
Apr 28, 2016·International Journal for Parasitology. Drugs and Drug Resistance·L CeballosC Lanusse
Nov 5, 2016·Veterinary Parasitology·Tania S WaghornDave M Leathwick
Jul 28, 2020·Expert Review of Anti-infective Therapy·Philip MiltonMaría-Gloria Basáñez
Mar 21, 2019·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Barbara Haline Buss BaiakRaquel Abdallah da Rocha
Jun 24, 2019·International Journal for Parasitology. Drugs and Drug Resistance·Roger K Prichard, Timothy G Geary
Oct 11, 2019·Acta Tropica·Dyego Gonçalves Lino BorgesFernando de Almeida Borges
May 26, 2020·Pharmaceutical Nanotechnology·Rodrigo Sanabria

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