Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Martin RittRoland E Schmieder

Abstract

Magnetic resonance imaging with arterial spin labeling (MRI-ASL) is a non-invasive approach to measure organ perfusion. We aimed to examine whether MRI-ASL kidney perfusion measurements are related to measurements of renal plasma flow (RPF) by para-aminohippuric acid (PAH) plasma clearance and whether changes of kidney perfusion in response to treatment with telmisartan can be detected by MRI-ASL. Twenty-four patients with metabolic syndrome and an estimated creatinine clearance according to Cockroft and Gault of > or =60 ml/min were included in the study. Kidney perfusion was assessed by MRI-ASL measurements of a single coronal kidney slice (with flow-sensitive alternating inversion recovery and true fast imaging with steady-state processing sequence) and by measurements of RPF using PAH plasma clearance before and after 2 weeks of treatment with the angiotensin receptor blocker telmisartan. All MRI-ASL examinations were performed on a 1.5 T scanner. Two weeks of therapy with telmisartan led to a significant increase of RPF (from 313 +/- 47 to 348 +/- 69 ml/min/m, P = 0.007) and MRI-ASL kidney perfusion measurements (from 253 +/- 20 to 268 +/- 25 ml/min/100 g, P = 0.020). RPF measurements were related with MRI-ASL kidney perfu...Continue Reading

References

Mar 24, 1984·British Medical Journal·G J WentingM A Schalekamp
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H Klinkmann, J Vienken
Mar 1, 1995·Journal of the American Society of Nephrology : JASN·R E SchmiederF H Messerli
Nov 1, 1993·Kidney International·S HellersteinB A Warady
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F CalamanteR Turner
Aug 10, 2000·Magnetic Resonance Imaging·N KargerC Glüer
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·E L BarbierM Décorps
Jan 1, 1959·Scandinavian Journal of Clinical and Laboratory Investigation·J BERGSTROML WERKO
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Petros MartirosianFritz Schick
Jul 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian DellesRoland E Schmieder
Oct 16, 2004·Investigative Radiology·Henrik J MichaelyMatthias Guenther
Feb 18, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserHermann Haller
Dec 17, 2005·Seminars in Nuclear Medicine·Nicolas GrenierVinçent Pérot
Mar 18, 2006·Nephron. Clinical Practice·Sabine E HaufeU Haberkorn
May 1, 1945·The Journal of Clinical Investigation·H W SmithM Graber
Dec 23, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin RittRoland E Schmieder

❮ Previous
Next ❯

Citations

Dec 21, 2012·Clinical and Experimental Pharmacology & Physiology·Per LissSue T Francis
Dec 17, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Markus P SchneiderRoland E Schmieder
Nov 12, 2013·Advances in Chronic Kidney Disease·Junjie ChenSamuel A Wickline
May 23, 2012·European Journal of Radiology·Xing Hui LiZhao Hua Zhai
May 19, 2011·Journal of Magnetic Resonance Imaging : JMRI·Nathan S ArtzSean B Fain
Apr 18, 2013·NMR in Biomedicine·Reshmi RajendranKai-Hsiang Chuang
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Reut AvniMichal Neeman
May 7, 2014·Journal of Magnetic Resonance Imaging : JMRI·Huan TanPottumarthi V Prasad
Jan 13, 2015·European Radiology·Tobias BreidthardtChristopher W McIntyre
Sep 21, 2010·Magnetic Resonance Imaging·Nathan S ArtzSean B Fain
May 14, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro ShimizuHirohiko Kimura
Oct 21, 2016·Nephron·Anton S Becker, Cristina Rossi
Apr 7, 2017·Journal of Magnetic Resonance Imaging : JMRI·José María Mora-GutiérrezMaría A Fernández-Seara
Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aghogho OduduMaría A Fernández-Seara
Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas M SelbySteven Sourbron
Mar 17, 2017·Clinical Journal of the American Society of Nephrology : CJASN·General LeungDarren A Yuen
Sep 13, 2018·Journal of the American Society of Nephrology : JASN·Bryan Thomas HaddockUlrik B Andersen
Dec 29, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Behzad EbrahimiLilach O Lerman
Apr 6, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Christian OttRoland E Schmieder
Mar 22, 2013·Critical Care : the Official Journal of the Critical Care Forum·Antione G SchneiderRinaldo Bellomo
Sep 3, 2011·Current Opinion in Nephrology and Hypertension·Ferruh ArtuncAndreas Boss
Sep 27, 2012·Current Opinion in Nephrology and Hypertension·Aghogho OduduChristopher W McIntyre
May 1, 2015·American Journal of Physiology. Renal Physiology·Katja HueperDagmar Hartung
Oct 6, 2017·American Journal of Physiology. Renal Physiology·Cesar A RomeroOscar A Carretero
Jan 19, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marissa J DeFreitasAlessia Fornoni
Mar 3, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ruud BuetersKendall S Frazier
Jun 1, 2012·American Journal of Physiology. Renal Physiology·Yupin P LiuBo Liu
Nov 28, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Seo Rin Kim, Lilach O Lerman
Oct 20, 2020·Current Opinion in Critical Care·Nicholas M Selby, Jacques Duranteau
Jul 3, 2021·Journal of Clinical Medicine·José María Mora-GutiérrezNuria Garcia-Fernandez
Aug 28, 2021·Journal of Personalized Medicine·Ling LinHildo J Lamb

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.