Measurement of left ventricular heat production in man

Medical & Biological Engineering & Computing
R E SmithA J Camm


A system to measure left ventricular heat production phi iv in conscious human subjects is described. Using phi iv and the rate of energy supply to the myocardium, the mechanical efficiency of the left ventricle is calculated. Heat carriage in left ventricular myocardial blood flow phi cs is calculated from coronary sinus flow and the transcoronary temperature difference. Diffusional heat loss phi diff is derived from the ratio of areas under temperature/time curves recorded in the aorta and coronary sinus after a bolus injection of cold saline into the pulmonary artery. The sum of phi cs, phi diff and phi chem (the energy of endothermic reactions with haemoglobin) gives phi iv. The estimated errors in the derived values of heat production and mechanical efficiency are less than 17 per cent. At basal heart rates 17 patients with good left ventricular function had a transcoronary temperature difference of 0.16 +/- 0.03 degrees C (mean +/- standard deviation), left ventricular flow blood of 145.3 +/- 81.5 ml min-1, and phi iv of 3.1 +/- 1.8 W. Left ventricular oxygen extraction was strongly correlated with phi iv (r = 0.925, p less than 0.001). Left ventricular mechanical efficiency was 0.33 +/- 0.11, at basal heart rates, which ...Continue Reading


Jul 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·A G Rakhlenko, I M Oksma
Jan 1, 1968·British Heart Journal·W B Hood
Jan 1, 1982·Circulation Research·G H ten VeldenN Westerhof
Feb 1, 1982·British Heart Journal·D S ThompsonM M Webb-Peploe
Sep 1, 1981·Medical & Biological Engineering & Computing·G JayaramanD Laurent
Feb 6, 1959·Annals of the New York Academy of Sciences·R J BING, G MICHAL
May 1, 1965·The American Journal of Physiology·S AFONSOC W CRUMPTON
Sep 1, 1961·Journal of Applied Physiology·W A NEILLR GORLIN

❮ Previous
Next ❯


Jan 22, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Thomas CuissetBernard De Bruyne
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K D YiR T Mallet

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.